An aldose reductase inhibitor
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Alrestatin

Item No. 29888

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-acetic acid
CAS Number
51411-04-2
Synonyms
  • AY 22284
  • NSC 299132
Molecular Formula
C14H9NO4
Formula Weight
255.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
λmax
213, 233, 332 nm
SMILES
O=C(C1=C2C(C=CC=C23)=CC=C1)N(CC(O)=O)C3=O
InChi Code
InChI=1S/C14H9NO4/c16-11(17)7-15-13(18)9-5-1-3-8-4-2-6-10(12(8)9)14(15)19/h1-6H,7H2,(H,16,17)
InChi Key
GCUCIFQCGJIRNT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $95

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    10 mg

    $149

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    25 mg

    $347

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    50 mg

    $1,047

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    Cayman Chemical
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    Product Description

    Alrestatin is an inhibitor of aldose reductase (IC50 = 1.5 µM for rat lens enzyme).1 It is selective for rat lens aldose reductase over rat kidney aldehyde reductase (IC50 = 58 µM). Alrestatin reduces basal and tyramine-induced norepinephrine release in rat pancreatic preparations.2 In vivo, alrestatin (0.75 mmol/kg) increases plasma insulin levels in fasted anesthetized rats. Alrestatin inhibits the lens and sciatic nerve accumulation of polyols in a rat model of streptozotocin-induced diabetes.3 It also inhibits gastric acid secretion and ulcer formation induced by pyloric ligation in rats (ED50s = 90 and 330 mg/kg, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sato, S., and Kador, P.F. Inhibition of aldehyde reductase by aldose reductase inhibitors. Biochem. Pharmacol. 40(5), 1033-1042 (1990).

    2. Kobric, M., and Lippmann, W. Effect of alrestatin sodium on glucose-stimulated insulin secretion in the fasted anaesthetized rat. Horm. Metab. Res. 10(6), 495-500 (1978).

    3. Lippmann, W., Seethaler, K., Borella, L.E., et al. Alrestatin: Gastric acid antisecretory-antiulcer activity in the rat. Digestion 18(1-2), 35-44 (1978).