A galanin receptor agonist
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Galnon (trifluoroacetate salt)

Item No. 29925

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-cyclohexyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-lysinamide, trifluoroacetate salt
CAS Number
1217448-19-5
Synonyms
  • Fmoc-β-Cha-Lys-AMC
Molecular Formula
C40H46N4O6 • CF3COOH
Formula Weight
792.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml
SMILES
O=C(N[C@@H](CC1CCCCC1)C(N[C@H](C(NC2=CC(OC(C=C3C)=O)=C3C=C2)=O)CCCCN)=O)OCC4C(C=CC=C5)=C5C6=C4C=CC=C6.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C40H46N4O6.C2HF3O2/c1-25-21-37(45)50-36-23-27(18-19-28(25)36)42-38(46)34(17-9-10-20-41)43-39(47)35(22-26-11-3-2-4-12-26)44-40(48)49-24-33-31-15-7-5-13-29(31)30-14-6-8-16-32(30)33;3-2(4,5)1(6)7/h5-8,13-16,18-19,21,23,26,33-35H,2-4,9-12,17,20,22,24,41H2,1H3,(H,42,46)(H,43,47)(H,44,48);(H,6,7)/t34-,35-;/m0./s1
InChi Key
NLKOPSMADZXEPE-WDAFUDAASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $103

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    10 mg

    $169

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    25 mg

    $378

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    Product Description

    Galnon is a galanin (GAL) receptor agonist (KD = 2.9 µM in Bowes cells expressing GAL1 receptors).1 It inhibits forskolin-induced adenylate cyclase activity in rat hippocampal membranes (EC50 = 10 µM). Galnon (2 mg/kg) reduces the maximal seizure score and increases the latency to first seizure in a mouse model of seizure induced by pentylenetetrazole (PTZ; Item No. 18682). It reduces cocaine-induced motor activity and frontal cortex, but not nucleus accumbens, dopamine overflow, as well as blocks cocaine-primed reinstatement of cocaine-seeking behavior in rats.2 Galnon (1.5-5 mg/kg) reduces food intake in rats and mice.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Saar, K., Mazarati, A.M., Mahlapuu, R., et al. Anticonvulsant activity of a nonpeptide galanin receptor agonist. Proc. Natl. Acad. Sci. USA 99(10), 7136-7141 (2002).

    2. Ogbonmwan, Y.E., Sciolino, N.R., Groves-Chapman, J.L., et al. The galanin receptor agonist, galnon, attenuates cocaine-induced reinstatement and dopamine overflow in the frontal cortex. Addict. Biol. 20(4), 701-713 (2015).

    3. Abramov, U., Florén, A., Echevarria, D.J., et al. Regulation of feeding by galnon. Neuropeptides 38(1), 55-61 (2004).