A glycoside with diverse biological activities
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Echinacoside

Item No. 29927

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(3,4-dihydroxyphenyl)ethyl O-6-deoxy-α-L-mannopyranosyl-(1→3)-O-[β-D-glucopyranosyl-(1→6)]-β-D-glucopyranoside, 4-[3-(3,4-dihydroxyphenyl)-2-propenoate]
CAS Number
82854-37-3
Synonyms
  • Kusaginin
  • NSC 603831
  • trans-Acteoside
  • trans-Verbascoside
Molecular Formula
C35H46O20
Formula Weight
786.7
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:9): 0.10 mg/mlEthanol: 5 mg/ml
λmax
219, 336 nm
SMILES
OC1=C(O)C=CC(/C=C/C(O[C@H]2[C@H](O[C@H]3[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)[C@@H](O)[C@H](OCCC4=CC=C(O)C(O)=C4)O[C@@H]2CO[C@H]5[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O5)=O)=C1
InChi Code
InChI=1S/C35H46O20/c1-14-24(42)26(44)29(47)35(51-14)55-32-30(48)34(49-9-8-16-3-6-18(38)20(40)11-16)53-22(13-50-33-28(46)27(45)25(43)21(12-36)52-33)31(32)54-23(41)7-4-15-2-5-17(37)19(39)10-15/h2-7,10-11,14,21-22,24-40,42-48H,8-9,12-13H2,1H3/b7-4+/t14-,21+,22+,24-,25+,26+,27-,28+,29+,30+,31+,32+,33+,34+,35-/m0/s1
InChi Key
FSBUXLDOLNLABB-ISAKITKMSA-N
Origin
Plant/Cistanches herba
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $69

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    10 mg

    $120

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    25 mg

    $263

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    50 mg

    $493

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    Product Description

    Echinacoside is a phenylethanoid glycoside that has been found in Echinacea and has diverse biological activities.1,2,3,4 It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals (EC50 = 6.6 µM in a cell-free assay).1 Echinacoside (10 µg/ml) inhibits hydrogen peroxide-induced production of reactive oxygen species (ROS) and apoptosis in PC12 cells.2 It reduces increases in plasma alanine aminotransferase (ALT), TNF-α, IL-1β, IL-16, and IL-10 levels and hepatocyte apoptosis induced by LPS/D-galactosamine in a mouse model of acute liver injury when administered at a dose of 60 mg/kg.3 Echinacoside (20 mg/kg per day for 15 days) prevents loss of dopaminergic neurons in the substantia nigra pars compacta and decreases in striatal dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) levels in a mouse model of MPTP-induced Parkinson's disease.4 It also improves motor performance in the rotarod test in the same model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pellati, F., Benvenuti, S., Magro, L., et al. Analysis of phenolic compounds and radical scavenging activity of Echinacea spp. J. Pharm. Biomed. Anal. 35(2), 289-301 (2004).

    2. Kuang, R., Sun, Y., Yuan, W., et al. Protective effects of echinacoside, one of the phenylethanoid glycosides, on H2O2-induced cytotoxicity in PC12 cells. Planta Med. 75(14), 1499-1504 (2009).

    3. Li, X., Gou, C., Yang, H., et al. Echinacoside ameliorates D-galactosamine plus lipopolysaccharide-induced acute liver injury in mice via inhibition of apoptosis and inflammation. Scand. J. Gastroenterol. 49(8), 993-1000 (2014).

    4. Geng, X., Tian, X., Tu, P., et al. Neuroprotective effects of echinacoside in the mouse MPTP model of Parkinson’s disease. Eur. J. Pharmacol. 564(1-3), 66-74 (2007).