A coumarin
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Isomer(s)
29930Seselin
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Xanthyletin

Item No. 29929

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8,8-dimethyl-2H,8H-Benzo[1,2-b:5,4-b′]dipyran-2-one
CAS Number
553-19-5
Synonyms
  • 2,2-Dimethylchromenocoumarin
Molecular Formula
C14H12O3
Formula Weight
228.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: soluble
SMILES
O=C1C=CC(C=C(C=CC(C)(C)O2)C2=C3)=C3O1
InChi Code
InChI=1S/C14H12O3/c1-14(2)6-5-10-7-9-3-4-13(15)16-11(9)8-12(10)17-14/h3-8H,1-2H3
InChi Key
QOTBQNVNUBKJMS-UHFFFAOYSA-N
Origin
Plant/Flindersia pimenteliana
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $267

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    5 mg

    $798

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    Product Description

    Xanthyletin is a coumarin that has been found in Z. avicennae and has diverse biological activities, including antifungal, antioxidant, and anticancer properties.1,2,3 It is active against the fungi R. solani, F. graminearum, and P. oryzae (IC50s = 49.1, 117.2, and 31.6 mg/L, respectively).1 Xanthyletin (50 mg/L) is also active against F. oxysporum, A. solani, and S. sclerotiorum. It reduces LPS-induced production of nitric oxide (NO) in BV-2 microglial cells with an IC50 value of 5.4 µM.2 Xanthyletin inhibits proliferation of A549 lung, MCF-7 breast, and PC3 prostate cancer cells (IC50s = 80.1, 19.3, and 97.2 µg/ml, respectively).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xiong, Y., Huang, G., Yao, Z., et al. Screening effective antifungal substances from the bark and leaves of Zanthoxylum avicennae by the bioactivity-guided isolation method. Molecules 24(23), E4207 (2019).

    2. Chan, Y.-Y., Li, C.-H., Shen, Y.-C., et al. Anti-inflammatory principles from the stem and root barks of Citrus medica. Chem. Pharm. Bull. (Tokyo) 58(1), 61-65 (2010).

    3. Tahsin, T., Wansi, J.D., Al-Groshi, A., et al. Cytotoxic properties of the stem bark of Citrus reticulata blanco (Rutaceae). Phytother. Res. 31(8), 1215-1219 (2017).