Seselin

Seselin is an angular pyranocoumarin that has been found in M. semecarpifolia and has diverse biological activities.^1,2,3,4 It is cytotoxic to P388 and HT-29 cells in vitro (EC₅₀s = 8.66 and 9.94 μg/ml).¹ Seselin (0.5, 4.5, and 40.5 mg/kg) reduces acetic acid-induced writhing in mice.² It also reduces paw licking in the first and second phases of the formalin test in mice when administered 30 minutes prior to formalin. Seselin (3, 10, and 30 mg/kg) decreases serum levels of IL-1β, IL-6, and TNF-α in a mouse model of sepsis induced by cecal ligation and puncture and increases survival when administered at a dose of 30 mg/kg.³ It reduces ear edema induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice (ED₄₅ = 0.25 mg/ear).⁴

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1. Chou, H.-C., Chen, J.-J., Duh, C.-Y., et al. Cytotoxic and anti-platelet aggregation constituents from the root wood of Melicope semecarpifolia. Planta Med. 71(11), 1078-1081 (2005).

2. Lima, V., Silva, C.B., Mafezoli, J., et al. Antinociceptive activity of the pyranocoumarin seselin in mice. Fitoterapia 77(7-8), 574-578 (2006).

3. Feng, L., Sun, Y., Song, P., et al. Seselin ameliorates inflammation via targeting Jak2 to suppress the proinflammatory phenotype of macrophages. Br. J. Pharmacol. 176(2), 317-333 (2019).

4. García-Argáez, A.N., Ramírez Apan, T.O., Parra Delgado, H., et al. Anti-inflammatory activity of coumarins from Decatropis bicolor on TPA ear mice model. Planta Med. 66(3), 279-281 (2000).