A neurotensin-like octapeptide
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Xenopsin

Item No. 29968

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-oxo-L-prolylglycyl-L-lysyl-L-arginyl-L-prolyl-L-tryptophyl-L-isoleucyl-L-leucine
CAS Number
51827-01-1
Synonyms
  • pGlu-Gly-Lys-Arg-Pro-Trp-Ile-Leu
Molecular Formula
C47H73N13O10
Formula Weight
980.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Water: 10 mg/ml
λmax
219 nm
SMILES
O=C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@@H]([C@H](CC)C)C(N[C@H](C(O)=O)CC(C)C)=O)=O)[C@H]3N(C([C@@H](NC([C@@H](NC(CNC([C@@H](N4)CCC4=O)=O)=O)CCCCN)=O)CCCNC(N)=N)=O)CCC3
InChi Code
InChI=1S/C47H73N13O10/c1-5-27(4)39(44(67)58-35(46(69)70)22-26(2)3)59-42(65)34(23-28-24-52-30-13-7-6-12-29(28)30)57-43(66)36-16-11-21-60(36)45(68)33(15-10-20-51-47(49)50)56-41(64)31(14-8-9-19-48)55-38(62)25-53-40(63)32-17-18-37(61)54-32/h6-7,12-13,24,26-27,31-36,39,52H,5,8-11,14-23,25,48H2,1-4H3,(H,53,63)(H,54,61)(H,55,62)(H,56,64)(H,57,66)(H,58,67)(H,59,65)(H,69,70)(H4,49,50,51)/t27-,31-,32-,33-,34-,35-,36-,39-/m0/s1
InChi Key
VVZLRNZUCNGJQY-KITDWFFGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $69

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    5 mg

    $297

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    10 mg

    $525

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    Product Description

    Xenopsin is a neurotensin-like octapeptide that has been found in X. laevis skin.1 It inhibits neurotensin (Item No. 24717) binding to rat brain synaptic membranes (Ki = 1.5 nM) and induces contraction of isolated guinea pig ileum in the presence of neostigmine (Item No. 23501; EC50 = 9 nM).2 Xenopsin (0.1 μM) increases the firing rate of dopaminergic neurons in rat substantia nigra slices by 58.5%.3 Intravenous infusion of xenopsin (2 μg/kg per hour) increases adrenal, pancreatic, and ileal blood flow and plasma levels of pancreatic polypeptide, glucagon, substance P, and cortisol, as well as reduces tetragastrin-induced gastric acid secretion in dogs.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zinner, M.J., Kasher, F., Modlin, I.M., et al. Effect of xenopsin on blood flow, hormone release, and acid secretion. Am. J. Physiol. 243(3), G195-199 (1982).

    2. Granier, C., van Rietschoten, J., Kitabgi, P., et al. Synthesis and characterization of neurotensin analogues for structure/activity relationship studies. Acetyl-neurotensin-(8--13) is the shortest analogue with full binding and pharmacological activities. Eur. J. Biochem. 124(1), 117-124 (1982).

    3. Pozza, M.F., Küng, E., Bischoff, S., et al. The neurotensin analog xenopsin excites nigral dopamine neurons. Eur. J. Pharmacol. 145(3), 341-343 (1988).