An orexin receptor 2 antagonist
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IPSU

Item No. 30007

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(1H-indol-3-ylmethyl)-9-(4-methoxy-2-pyrimidinyl)-2,9-diazaspiro[5.5]undecan-1-one
CAS Number
1373765-19-5
Molecular Formula
C23H27N5O2
Formula Weight
405.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
λmax
220, 246 nm
SMILES
O=C1C2(CCN(C3=NC(OC)=CC=N3)CC2)CCCN1CC4=CNC5=CC=CC=C54
InChi Code
InChI=1S/C23H27N5O2/c1-30-20-7-11-24-22(26-20)27-13-9-23(10-14-27)8-4-12-28(21(23)29)16-17-15-25-19-6-3-2-5-18(17)19/h2-3,5-7,11,15,25H,4,8-10,12-14,16H2,1H3
InChi Key
PCMHOSYCWRRHTG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $32

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    5 mg

    $141

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    10 mg

    $248

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    25 mg

    $542

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    Product Description

    IPSU is a potent orexin receptor 2 (OX2R) antagonist (Ki = 14.13 nM).1 It is selective for OX2R over OX1R (Ki = 512.8 nM). IPSU (50 mg/kg) increases non-rapid eye movement (NREM) sleep in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Betschart, C., Hintermann, S., Behnke, D., et al. Identification of a novel series of orexin receptor antagonists with a distinct effect on sleep architecture for the treatment of insomnia. J. Med. Chem. 56(19), 7590-7607 (2013).