A peptide ETB receptor agonist
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Sarafotoxin S6c (trifluoroacetate salt)

Item No. 30040

Product Insert (PDF)
Technical Information
Formal Name
L-cysteinyl-L-threonyl-L-cysteinyl-L-asparaginyl-L-α-aspartyl-L-methionyl-L-threonyl-L-α-aspartyl-L-α-glutamyl-L-α-glutamyl-L-cysteinyl-L-leucyl-L-asparaginyl-L-phenylalanyl-L-cysteinyl-L-histidyl-L-glutaminyl-L-α-aspartyl-L-valyl-L-isoleucyl-L-tryptophan, cyclic (1→15),(3→11)-bis(disulfide), trifluoroacetate salt
Synonyms
  • SRTX-c
  • STX-S6c
Molecular Formula
C103H147N27O37S5 • XCF3COOH
Formula Weight
2515.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
CTCNDMTDEECLNFCHQDVIW-OH
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/ml
SMILES
O=C(N[C@]([C@H](O)C)([H])C(N[C@@H](CSSC[C@H](N1)C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@H](C2=O)CC3=CC=CC=C3)=O)=O)CC(C)C)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CCSC)C(N[C@]([C@H](O)C)([H])C(N[C@@H](CC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C1=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CSSC[C@H](N2)C(N[C@@H](CC4=CNC=N4)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N[C@@](C(N[C@@H](CC5=CNC6=C5C=CC=C6)C(O)=O)=O)([H])[C@@H](C)CC)=O)=O)=O)=O)=O)N[H].FC(F)(F)C(O)=O
InChi Code
InChI=1S/C103H147N27O37S5.C2HF3O2/c1-10-46(6)80(100(163)123-67(103(166)167)30-50-37-109-54-19-15-14-18-52(50)54)128-99(162)79(45(4)5)127-95(158)66(36-78(144)145)120-85(148)55(20-23-71(105)133)112-90(153)61(31-51-38-108-43-110-51)117-97(160)69-40-170-169-39-53(104)83(146)129-81(47(7)131)102(165)126-70-42-172-171-41-68(96(159)115-59(28-44(2)3)88(151)118-62(32-72(106)134)91(154)116-60(89(152)125-69)29-49-16-12-11-13-17-49)124-86(149)57(22-25-75(138)139)111-84(147)56(21-24-74(136)137)113-94(157)65(35-77(142)143)122-101(164)82(48(8)132)130-87(150)58(26-27-168-9)114-93(156)64(34-76(140)141)121-92(155)63(33-73(107)135)119-98(70)161;3-2(4,5)1(6)7/h11-19,37-38,43-48,53,55-70,79-82,109,131-132H,10,20-36,39-42,104H2,1-9H3,(H2,105,133)(H2,106,134)(H2,107,135)(H,108,110)(H,111,147)(H,112,153)(H,113,157)(H,114,156)(H,115,159)(H,116,154)(H,117,160)(H,118,151)(H,119,161)(H,120,148)(H,121,155)(H,122,164)(H,123,163)(H,124,149)(H,125,152)(H,126,165)(H,127,158)(H,128,162)(H,129,146)(H,130,150)(H,136,137)(H,138,139)(H,140,141)(H,142,143)(H,144,145)(H,166,167);(H,6,7)/t46-,47+,48+,53-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,79-,80-,81-,82-;/m0./s1
InChi Key
HWSGKTVIILWOKU-FRTCUJHUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Sarafotoxin S6c is a snake venom-derived toxin and peptide endothelin type B (ETB) receptor agonist.1,2 It induces phosphatidyl inositol turnover in rat hippocampal slices, which endogenously express the ETB receptor, with an EC50 value of approximately 10 nM.2 Sarafotoxin S6c selectively binds to the ETB receptor over the ETA receptor (Kis = 0.023 and 4,200 nM for the rat hippocampal and atrial receptors, respectively).2 It induces contractions in isolated dog saphenous vein segments and relaxation of isolated rabbit mesenteric artery segments in a concentration-dependent manner.3 It increases diastolic arterial pressure in pithed rats when administered at doses ranging from 0.01 to 3 nmol/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

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