A peptide agonist of δ-opioid receptors
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Deltorphin C (trifluoroacetate salt)

Item No. 30050

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-tyrosyl-D-alanyl-L-phenylalanyl-L-α-aspartyl-L-valyl-L-valyl-glycinamide, trifluoroacetate salt
Synonyms
  • Deltorphin I
  • [D-Ala2]Deltorphin
Molecular Formula
C37H52N8O10 • XCF3COOH
Formula Weight
768.9
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/mlEthanol: 1 mg/ml
SMILES
OC1=CC=C(C[C@H](N)C(N[C@H](C)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(NCC(N)=O)=O)=O)=O)=O)=O)=O)C=C1.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C37H52N8O10.C2HF3O2/c1-19(2)30(36(54)40-18-28(39)47)45-37(55)31(20(3)4)44-35(53)27(17-29(48)49)43-34(52)26(16-22-9-7-6-8-10-22)42-32(50)21(5)41-33(51)25(38)15-23-11-13-24(46)14-12-23;3-2(4,5)1(6)7/h6-14,19-21,25-27,30-31,46H,15-18,38H2,1-5H3,(H2,39,47)(H,40,54)(H,41,51)(H,42,50)(H,43,52)(H,44,53)(H,45,55)(H,48,49);(H,6,7)/t21-,25+,26+,27+,30+,31+;/m1./s1
InChi Key
WVISKLVQEKTHGN-JXLAAAJESA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $153

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    10 mg

    $268

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    25 mg

    $587

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    Product Description

    Deltorphin C is a peptide agonist of δ-opioid receptors (Ki = 0.15 nM) that has been found in Phyllomedusa bicolor.1 It is selective for δ-opioid receptors over µ- and ĸ-opioid receptors. It induces δ-opioid receptor translocation from large dense-core vesicles to the cell surface and induces calcitonin gene-related peptide (CGRP) release in isolated mouse dorsal root ganglion (DRG) cells when used at concentrations of 0.1 and 1 µM, respectively, effects that can be blocked with the δ-opioid receptor antagonist naltrindole (Item No. 9000705).2 Intrathecal administration of deltorphin C (0.15, 1.5, and 15 µg/animal) increases latency to withdraw in the paw pressure and tail-flick tests in rats.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Erspamer, V., Melchiorri, P., Falconieri-Erspamer, G., et al. Deltorphins: A family of naturally occurring peptides with high affinity and selectivity for delta opioid binding sites. Proc. Natl. Acad. Sci. USA 86(13), 5188-5192 (1989).

    2. Bao, L., Jin, S.-X., Zhang, C., et al. Activation of delta opioid receptors induces receptor insertion and neuropeptide secretion. Neuron 37(1), 121-133 (2003).

    3. Labuz, D., Toth, G., Machelska, H., et al. Antinociceptive effects of isoleucine derivatives of deltorphin I and deltorphin II in rat spinal cord: A search for selectivity of delta receptor subtypes. Neuropeptides 32(6), 511-517 (1998).