A phenylethanoid glycoside with diverse biological activities
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Forsythoside A

Item No. 30110

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(3,4-dihydroxyphenyl)ethyl 6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-Glucopyranoside, 4-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate]
CAS Number
79916-77-1
Synonyms
  • Forsythiaside
Molecular Formula
C29H36O15
Formula Weight
624.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 10 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
220, 333 nm
SMILES
OC(C=C1)=C(O)C=C1CCO[C@@H]2O[C@H](CO[C@H]3[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)[C@@H](OC(/C=C/C4=CC=C(O)C(O)=C4)=O)[C@H](O)[C@H]2O
InChi Code
InChI=1S/C29H36O15/c1-13-22(35)23(36)25(38)29(42-13)41-12-20-27(44-21(34)7-4-14-2-5-16(30)18(32)10-14)24(37)26(39)28(43-20)40-9-8-15-3-6-17(31)19(33)11-15/h2-7,10-11,13,20,22-33,35-39H,8-9,12H2,1H3/b7-4+/t13-,20+,22-,23+,24+,25+,26+,27+,28+,29+/m0/s1
InChi Key
DTOUWTJYUCZJQD-UJERWXFOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Cayman Chemical
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    Product Description

    Forsythoside A is a phenylethanoid glycoside that has been found in F. suspensa and has diverse biological activities.1,2,3,4 It is active against E. coli, P. aeruginosa, and S. aureus (MICs = 38.33, 38.33, and 76.67 µg/ml, respectively).1 Forsythoside A scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals with an EC50 value of 6.3 µg/ml. It reduces apoptosis induced by amyloid-β (25-35) (Aβ (25-35)) in PC12 cells when used at concentrations of 10 and 25 µM.3 Forsythoside A (15, 30, and 60 mg/kg per day) reduces increases in bronchoalveolar lavage fluid (BALF) levels of TNF-α, IL-6, and IL-1β and neutrophil and macrophage infiltration induced by cigarette smoke in a mouse model of chronic obstructive pulmonary disease (COPD).2 It decreases the latency mice take to find the platform in the Morris water maze in the SAMP8 model of rapid aging and dementia when administered at doses of 120 and 240 mg/kg per day.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Qu, H., Zhang, Y., Wang, Y., et al. Antioxidant and antibacterial activity of two compounds (forsythiaside and forsythin) isolated from Forsythia suspensa. J. Pharm. Pharmacol. 60(2), 261-266 (2008).

    2. Cheng, L., Li, F., Ma, R., et al. Forsythiaside inhibits cigarette smoke-induced lung inflammation by activation of Nrf2 and inhibition of NF-κB. Int. Immunopharmacol. 28(1), 494-499 (2015).

    3. Yan, X., Chen, T., Zhang, L., et al. Protective effects of Forsythoside A on amyloid beta-induced apoptosis in PC12 cells by downregulating acetylcholinesterase. Eur. J. Pharmacol. 810, 141-148 (2017).

    4. Wang, H.-M., Wang, L.-W., Liu, X.-M., et al. Neuroprotective effects of forsythiaside on learning and memory deficits in senescence-accelerated mouse prone (SAMP8) mice. Pharmacol. Biochem. Behav. 105, 134-141 (2013).