An active metabolite of chloroquine
Related Products
Labeled Version(s)
30907Desethylchloroquine-d4
Parent Compound(s)
14194Chloroquine (phosphate)
Technical Support & Resources

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Desethylchloroquine

Item No. 30113

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N4-(7-chloro-4-quinolinyl)-N1-ethyl-1,4-pentanediamine
CAS Number
1476-52-4
Synonyms
  • N-Desethylchloroquine
  • NSC 13254
Molecular Formula
C16H22ClN3
Formula Weight
291.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly solubleMethanol: Slightly soluble
SMILES
CCNCCCC(C)NC1=CC=NC2=C1C=CC(Cl)=C2
InChi Code
InChI=1S/C16H22ClN3/c1-3-18-9-4-5-12(2)20-15-8-10-19-16-11-13(17)6-7-14(15)16/h6-8,10-12,18H,3-5,9H2,1-2H3,(H,19,20)
InChi Key
MCYUUUTUAAGOOT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $134

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    5 mg

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    10 mg

    $795

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    Product Description

    Desethylchloroquine is a major active metabolite of chloroquine (Item No. 14194).1 Desethylchloroquine is formed when chloroquine undergoes dealkylation, primarily by the cytochrome P450 (CYP) isoforms CYP2C8 and CYP3A4 and to a lesser extent by CYP2D6. It inhibits the growth of the P. falciparum strain LA136 in vitro (IC50 = 9.9 ng/ml).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Projean, D., Baune, B., Farinotti, R., et al. In vitro metabolism of chloroquine: Identification of CYP2C8, CYP3A4, and CYP2D6 as the main isoforms catalyzing N-desethylchloroquine formation. Drug Metab. Dispos. 31(6), 748-754 (2003).

    2. Aderounmu, F.A. In vitro assessment of the antimalarial activity of chloroquine and its major metabolites. Ann. Trop. Med. Parasitol. 78(6), 581-585 (1984).