An internal standard for the quantification of diosmetin
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Unlabeled Version(s)
18649Diosmetin
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Diosmetin-d3

Item No. 30122

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,7-dihydroxy-2-(3-hydroxy-4-methoxy-d3-phenyl)-4H-1-benzopyran-4-one
CAS Number
1189728-54-8
Synonyms
  • Diosmetol-d3
  • Luteolin 4'-methyl ester-d3
Molecular Formula
C16H9D3O6
Formula Weight
303.3
Purity
≥99% deuterated forms (d1-d3)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solubleMethanol: slightly soluble
SMILES
O=C1C=C(C2=CC=C(OC([2H])([2H])[2H])C(O)=C2)OC3=CC(O)=CC(O)=C31
InChi Code
InChI=1S/C16H12O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-7,17-19H,1H3/i1D3
InChi Key
MBNGWHIJMBWFHU-FIBGUPNXSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $107

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    Product Description

    Diosmetin-d3 is intended for use as an internal standard for the quantification of diosmetin (Item No. 18649) by GC- or LC-MS. Diosmetin is a flavonoid that has been found in citrus fruits and has diverse biological activities.1,2,3,4 It inhibits the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1B1 (Kis = 89 and 16 nM, respectively).1 Diosmetin prevents increases in erythrocyte reactive oxygen species (ROS) and malondialdehyde (MDA) levels induced by AAPH (Item No. 82235) in a concentration-dependent manner.2 It reduces tumor growth and tumor blood vessel density in a B16/F10 murine melanoma model when administered at a dose of 1 mg/kg twice per day.3 Diosmetin (0.5 mg/kg) inhibits lung goblet cell hyperplasia and collagen deposition and decreases the number of eosinophils and neutrophils in bronchoalveolar lavage fluid (BALF) in a mouse model of chronic asthma induced by ovalbumin.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Androutsopoulos, V.P., Papakyriakou, A., Vourloumis, D., et al. Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids. Bioorg. Med. Chem. 19(9), 2842-2849 (2011).

    2. Liao, W., Ning, Z., Chen, L., et al. Intracellular antioxidant detoxifying effects of diosmetin on 2,2-azobis(2-amidinopropane) dihydrochloride (AAPH)-induced oxidative stress through inhibition of reactive oxygen species generation. J. Agric. Food Chem. 62(34), 8648-8654 (2014).

    3. Choi, J., Lee, D.H., Park, S.Y., et al. Diosmetin inhibits tumor development and block tumor angiogenesis in skin cancer. Biomed. Pharmacother. 117, 109091 (2019).

    4. Ge, A., Liu, Y., Zeng, X., et al. Effect of diosmetin on airway remodeling in a murine model of chronic asthma. Acta Biochim. Biophys. Sin. (Shanghai) 47(8), 604-611 (2015).