A triterpene with diverse biological activities
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Erythrodiol

Item No. 30135

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β)-olean-12-ene-3,28-diol
CAS Number
545-48-2
Synonyms
  • (+)-Erythrodiol
  • 3β-Erythrodiol
  • Oleanolic Alcohol
Molecular Formula
C30H50O2
Formula Weight
442.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMF:PBS (pH 7.2) (1:8): 0.1 mg/mlEthanol: 1 mg/ml
SMILES
CC1(C)CC[C@]2(CO)CC[C@@]3(C)[C@]4(C)CC[C@@]5([H])C(C)(C)[C@@H](O)CC[C@]5(C)[C@@]4([H])CC=C3[C@]2([H])C1
InChi Code
InChI=1S/C30H50O2/c1-25(2)14-16-30(19-31)17-15-28(6)20(21(30)18-25)8-9-23-27(5)12-11-24(32)26(3,4)22(27)10-13-29(23,28)7/h8,21-24,31-32H,9-19H2,1-7H3/t21-,22-,23+,24-,27-,28+,29+,30+/m0/s1
InChi Key
PSZDOEIIIJFCFE-OSQDELBUSA-N
Origin
Plant/Pittosporum tobira leaf
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $90

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    10 mg

    $158

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    25 mg

    $349

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    50 mg

    $609

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    Product Description

    Erythrodiol is a triterpene that has been found in olive oil and has diverse biological activities.1,2,3,4 It induces relaxation of isolated rat aortic rings precontracted with phenylephrine (EC50 = 3.38 µM).1 Erythrodiol inhibits the growth of HT-29 adenocarcinoma cells (EC50 = 48.8 µM).2 It induces production of reactive oxygen species (ROS) and apoptosis in MCF-7 cells when used at a concentration of 100 µM.3 Topical administration of erythrodiol (0.5 mg/ear) reduces ear edema and myeloperoxidase (MPO) activity induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rodríguez-Rodríguez, R., Herrera, M.D., Perona, J.S., et al. Potential vasorelaxant effects of oleanolic acid and erythrodiol, two triterpenoids contained in “orujo” olive oil, on rat aorta. Br. J. Nutr. 92(4), 635-642 (2004).

    2. Juan, M.E., Wenzel, U., Daniel, H., et al. Erythrodiol, a natural triterpenoid from olives, has antiproliferative and apoptotic activity in HT-29 human adenocarcinoma cells. Mol. Nutr. Food Res. 52(5), 595-599 (2008).

    3. Allouche, Y., Warleta, F., Campos, M., et al. Antioxidant, antiproliferative, and pro-apoptotic capacities of pentacyclic triterpenes found in the skin of olives on MCF-7 human breast cancer cells and their effects on DNA damage. J. Agric. Food Chem. 59(1), 121-130 (2011).

    4. Máñez, S., Recio, M.C., Giner, R.M., et al. Effect of selected triterpenoids on chronic dermal inflammation. Eur. J. Pharmacol. 334(1), 103-105 (1997).