Uvaol

Uvaol is a pentacyclic triterpenoid that has been found in olive (O. europaea) leaves and has diverse biological activities.^1,2,3,4 It induces cell cycle arrest at the G₀/G₁ phase and inhibits proliferation of MCF-7 human breast cancer cells in a concentration-dependent manner.² Uvaol (10 µM) prevents hydrogen peroxide-induced DNA damage in the same cells. It induces relaxation of phenylephrine- or potassium chloride-precontracted aortic rings isolated from spontaneously hypertensive rats when used at a concentration of 100 µM.³ Uvaol (200 and 500 µmol/kg) inhibits ovalbumin-induced bronchoalveolar lavage fluid (BALF) eosinophil infiltration in an ovalbumin-sensitized mouse model of allergic asthma.⁴

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1. Guinda, A., Rada, M., Delgado, T., et al. Pentacyclic triterpenoids from olive fruit and leaf. J. Agric. Food Chem. 58(17), 9685-9691 (2010).

2. Allouche, Y., Warleta, F., Campos, M., et al. Antioxidant, antiproliferative, and pro-apoptotic capacities of pentacyclic triterpenes found in the skin of olives on MCF-7 human breast cancer cells and their effects on DNA damage. J. Agric. Food Chem. 59(1), 121-130 (2011).

3. Rodriguez-Rodriguez, R., Perona, J.S., Herrera, M.D., et al. Triterpenic compounds from "orujo" olive oil elicit vasorelaxation in aorta from spontaneously hypertensive rats. J. Agric. Food Chem. 54(6), 2096-2102 (2006).

4. Agra, L.C., Lins, M.P., da Silva Marques, P., et al. Uvaol attenuates pleuritis and eosinophilic inflammation in ovalbumin-induced allergy in mice. Eur. J. Pharmacol. 780, 232-242 (2016).