A STING inhibitor
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C-170

Item No. 30157

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-butylphenyl)-5-nitro-2-furancarboxamide
CAS Number
346691-38-1
Molecular Formula
C15H16N2O4
Formula Weight
288.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
λmax
254, 304 nm
SMILES
CCCCC1=CC=C(NC(C2=CC=C([N+]([O-])=O)O2)=O)C=C1
InChi Code
InChI=1S/C15H16N2O4/c1-2-3-4-11-5-7-12(8-6-11)16-15(18)13-9-10-14(21-13)17(19)20/h5-10H,2-4H2,1H3,(H,16,18)
InChi Key
QMVOHFICEFYHMK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    10 mg

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    Cayman Chemical
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    Product Description

    C-170 is an inhibitor of stimulator of interferon genes (STING).1,2 It binds to STING, inhibits its palmitoylation, and prevents the recruitment and phosphorylation of TBK1.1 It selectively reduces human and mouse STING-, but not RIG-I- or TBK1-, mediated IFN-β reporter activity in HEK293 cells when used at concentrations ranging from 0.02 to 2 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Haag, S.M., Gulen, M.F., Reymond, L., et al. Targeting STING with covalent small-molecule inhibitors. Nature 559(7713), 269-273 (2018).

    2. Zhang, H., You, Q.-D., and Xu, X.-L. Targeting stimulator of interferon genes (STING): A medicinal chemistry perspective. J. Med. Chem. 63(8), 3785-3816 (2019).