An RORγt antagonist
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ML-209

Item No. 30164

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
rel-3-(1,3-benzodioxol-5-yl)-1-[(3R,5S)-3,5-dimethyl-1-piperidinyl]-3-(2-hydroxy-4,6-dimethoxyphenyl)-1-propanone
CAS Number
1334526-14-5
Molecular Formula
C25H31NO6
Formula Weight
441.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mM
SMILES
C[C@@H]1C[C@H](C)CN(C(CC(C2=CC(OCO3)=C3C=C2)C4=C(O)C=C(OC)C=C4OC)=O)C1
InChi Code
InChI=1S/C25H31NO6/c1-15-7-16(2)13-26(12-15)24(28)11-19(17-5-6-21-22(8-17)32-14-31-21)25-20(27)9-18(29-3)10-23(25)30-4/h5-6,8-10,15-16,19,27H,7,11-14H2,1-4H3/t15-,16+,19?
InChi Key
YEKVAIMYYCZDLI-MCPYQZEQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $69

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    1 mg

    $127

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    5 mg

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    Product Description

    ML-209 is an antagonist of retinoic acid receptor-related orphan receptor γt (RORγt; IC50 = 1.1 µM in a reporter assay).1 It inhibits RORγt-induced transcription in HEK293T cells expressing the human receptor (IC50 = 300 nM). ML-209 inhibits RORγt-dependent differentiation of isolated naïve cord blood human CD4+ T cells into Th17 T helper cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Huh, J.R., Englund, E.E., Wang, H., et al. Identification of potent and selective diphenylpropanamide RORγ inhibitors. ACS Med. Chem. Lett. 4(1), 79-84 (2013).