A DPP-4 inhibitor
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DPPI 1c (hydrochloride)

Item No. 30211

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R,5S)-rel-1-[2-[[1-(hydroxymethyl)cyclopentyl]amino]acetyl]-2,5-pyrrolidinedicarbonitrile, monohydrochloride
CAS Number
866396-70-5
Molecular Formula
C14H20N4O2 • HCl
Formula Weight
312.8
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mMEthanol: 25 mMWater: 50 mM
SMILES
O=C(CNC1(CO)CCCC1)N2[C@@H](C#N)CC[C@H]2C#N.Cl
InChi Code
InChI=1S/C14H20N4O2.ClH/c15-7-11-3-4-12(8-16)18(11)13(20)9-17-14(10-19)5-1-2-6-14;/h11-12,17,19H,1-6,9-10H2;1H/t11-,12+;
InChi Key
RHCWAHDCHQTNBR-IWKKHLOMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $69

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    1 mg

    $127

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    5 mg

    $248

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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    DPPI 1c is an inhibitor of dipeptidyl peptidase 4 (DPP-4; IC50 = 104 nM in an enzyme assay).1 It decreases plasma glucose levels by 46 to 67% in an oral glucose challenge in fasted, diabetic KK/H1J mice when administered at doses ranging from 0.3 to 5 mg/kg. DPPI 1c decreases plasma DPP-4 activity by approximately 50% and increases plasma glucagon-like peptide 1 (GLP-1) levels in KK/H1J mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wright, S.W., Ammirati, M.J., Andrews, K.M., et al. cis-2,5-Dicyanopyrrolidine inhibitors of dipeptidyl peptidase IV: Synthesis and in vitro, in vivo, and X-ray crystallographic characterization. J. Med. Chem. 49(11), 3068-3076 (2006).