An agonist of FFAR1/GPR40 and PPARδ
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HWL-088

Item No. 30227

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[2-fluoro-4-[(2′-methyl[1,1′-biphenyl]-3-yl)methoxy]phenoxy]-acetic acid
CAS Number
2378617-96-8
Molecular Formula
C22H19FO4
Formula Weight
366.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Soluble
SMILES
CC1=CC=CC=C1C2=CC(COC3=CC=C(OCC(O)=O)C(F)=C3)=CC=C2
InChi Code
InChI=1S/C22H19FO4/c1-15-5-2-3-8-19(15)17-7-4-6-16(11-17)13-26-18-9-10-21(20(23)12-18)27-14-22(24)25/h2-12H,13-14H2,1H3,(H,24,25)
InChi Key
NJYJBYPNDWNZAH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $54

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    1 mg

    $257

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    5 mg

    $486

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    HWL-088 is an agonist of free fatty acid receptor 1 (FFAR1/GPR40) and peroxisome proliferator-activated receptor δ (PPARδ).1 It induces calcium mobilization in CHO cells expressing human FFAR1/GPR40 (EC50 = 18.9 nM) and transactivation of PPARδ in a reporter assay using HEK293 cells (EC50 = 570.9 nM). HWL-088 is selective for FFAR1/GPR40 and PPARδ over PPARα and PPARγ. It decreases plasma glucose, hemoglobin A1c (HbA1c), total cholesterol, triglyceride, and LDL levels, increases plasma insulin levels, and reduces hepatic lipid accumulation in ob/ob mice when administered at a dose of 40 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, Y., Ren, Q., Zhou, Z., et al. HWL-088, a new potent free fatty acid receptor 1 (FFAR1) agonist, improves glucolipid metabolism and acts additively with metformin in ob/ob diabetic mice. Br. J. Pharmacol. 177(10), 2286-2302 (2019).