An internal standard for the quantification of praziquantel
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Unlabeled Version(s)
20508Praziquantel
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Praziquantel-d11

Item No. 30237

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(cyclohexyl-1,2,2,3,3,4,4,5,5,6,6-d11-carbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a ]isoquinolin-4-one
CAS Number
1246343-36-1
Synonyms
  • (±)-Praziquantel-d11
Molecular Formula
C19H13D11N2O2
Formula Weight
323.5
Purity
≥99% deuterated forms (d1-d11)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: solubleMethanol: soluble
SMILES
O=C(N1CC(C(C=CC=C2)=C2CC3)N3C(C1)=O)C4([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C4([2H])[2H]
InChi Code
InChI=1S/C19H24N2O2/c22-18-13-20(19(23)15-7-2-1-3-8-15)12-17-16-9-5-4-6-14(16)10-11-21(17)18/h4-6,9,15,17H,1-3,7-8,10-13H2/i1D2,2D2,3D2,7D2,8D2,15D
InChi Key
FSVJFNAIGNNGKK-DHCOBZMXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Cayman Chemical
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    Product Description

    Praziquantel-d11 is intended for use as an internal standard for the quantification of praziquantel (Item No. 20508) by GC- or LC-MS. Praziquantel is an anthelmintic agent.1,2 It is lethal to S. mansoni schistosomula and adults (LC50s = 0.68 and 0.03 mg/ml, respectively).2 Praziquantel (172 and 592 mg/kg) reduces worm burden in a mouse model of S. mansoni infection. Formulations containing praziquantel have been used in the treatment of schistosomiasis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cook, G.C. Anthelminthic agents: Some recent developments and their clinical application. Postgrad. Med. J. 67(783), 16-22 (1991).

    2. Olliaro, P., Delgado-Romero, P., and Keiser, J. The little we know about the pharmacokinetics and pharmacodynamics of praziquantel (racemate and R-enantiomer). J. Antimicrob. Chemother. 69(4), 863-870 (2014).