A flavonoid with diverse biological activities
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Isomer(s)
30270Isoliquiritin
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Liquiritin

Item No. 30263

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S)-2-[4-(β-D-glucopyranosyloxy)phenyl]-2,3-dihydro-7-hydroxy-4H-1-benzopyran-4-one
CAS Number
551-15-5
Molecular Formula
C21H22O9
Formula Weight
418.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30mg/mLDMF:PBS (pH 7.2) (1:20): 0.04mg/mLDMSO: 20mg/mL
λmax
218, 277, 312 nm
SMILES
OC(C=C1)=CC2=C1C(C[C@@H](C3=CC=C(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C=C3)O2)=O
InChi Code
InChI=1S/C21H22O9/c22-9-17-18(25)19(26)20(27)21(30-17)28-12-4-1-10(2-5-12)15-8-14(24)13-6-3-11(23)7-16(13)29-15/h1-7,15,17-23,25-27H,8-9H2/t15-,17+,18+,19-,20+,21+/m0/s1
InChi Key
DEMKZLAVQYISIA-ZRWXNEIDSA-N
Origin
Plant/Glycyrrhiza uralensis
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $75

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    10 mg

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    25 mg

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    50 mg

    $369

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    Product Description

    Liquiritin is a flavonoid that has been found in Glycyrrhiza and has diverse biological activities.1,2,3 It inhibits corticosterone-induced apoptosis in PC12 cells when used at concentrations of 1 and 2 mg/ml.1 Liquiritin (120 mg/kg) reduces spinal cord levels of IL-1β, IL-6, and TNF-α and alleviates mechanical and cold allodynia, as well as thermal hyperalgesia, in a mouse model of neuropathic pain induced by chronic constriction injury (CCI) of the sciatic nerve.2 It decreases the viability of SiHa, CaSki, and HeLa cervical cancer cells and inhibits migration and invasion of SiHa cells in vitro when used at concentrations of 40, 60, and 80 μM.3 Liquiritin (10, 20, and 30 mg/kg) reduces tumor growth in a SiHa mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wu, J., Huang, F.X., Wang, J., et al. Protective effect of liquiritin on corticosterone-induced neurotoxicity in PC12 cells. Trop. J. Pharm. Res. 17(10), 2013-2017 (2018).

    2. Zhang, M.-T., Wang, B., Jia, Y.-N., et al. Neuroprotective effect of liquiritin against neuropathic pain induced by chronic constriction injury of the sciatic nerve in mice. Biomed. Pharmacother. 95, 186-198 (2017).

    3. He, S.-H., Liu, H.-G., Zhou, Y.-F., et al. Liquiritin (LT) exhibits suppressive effects against the growth of human cervical cancer cells through activating caspase-3 in vitro and xenograft mice in vivo. Biomed. Pharmacother. 92, 215-228 (2017).