An amino acid
Related Products
Isomer(s)
30852L-Homocysteine
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DL-Homocysteine

Item No. 30285

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
454-29-5
Synonyms
  • NSC 206252
Molecular Formula
C4H9NO2S
Formula Weight
135.2
Purity
≥90%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
SCCC(N)C(O)=O
InChi Code
InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)
InChi Key
FFFHZYDWPBMWHY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 mg

    $37

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    1 g

    $69

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    Product Description

    DL-Homocysteine is a thiol-containing amino acid derived from methionine.1 It inhibits vasodilation of precontracted isolated guinea pig pulmonary artery rings induced by acetylcholine (ACh) and enhances potassium chloride- and phenylephrine-induced contraction of isolated guinea pig pulmonary artery rings.2 DL-Homocysteine (200 µM) inhibits endothelium-dependent ACh-induced vasodilation in the vascular bed of isolated perfused rat pancreas.3 Elevated plasma levels of DL-homocysteine are positively correlated with occlusive arterial diseases and atherosclerosis.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pushpakumar, S., Kundu, S., and Sen, U. Endothelial dysfunction: The link between homocysteine and hydrogen sulfide. Curr. Med. Chem. 21(32), 3662-3672 (2014).

    2. Tasatargil, A., Sadan, G., and Karasu, E. Homocysteine-induced changes in vascular reactivity of guinea-pig pulmonary arteries: Role of the oxidative stress and poly (ADP-ribose) polymerase activation. Pulm. Pharmacol. Ther. 20(3), 265-272 (2007).

    3. Quéré, I., Hillaire-Buys, D., Brunschwig, C., et al. Effects of homocysteine on acetylcholine- and adenosine-induced vasodilatation of pancreatic vascular bed in rats. Br. J. Pharmacol. 122(2), 351-357 (1997).