An esterified form of NAC
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N-acetyl-L-Cysteine ethyl ester

Item No. 30299

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
59587-09-6
Synonyms
  • NACET
  • NAC ethyl ester
Molecular Formula
C7H13NO3S
Formula Weight
191.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
SMILES
SC[C@H](NC(C)=O)C(OCC)=O
InChi Code
InChI=1S/C7H13NO3S/c1-3-11-7(10)6(4-12)8-5(2)9/h6,12H,3-4H2,1-2H3,(H,8,9)/t6-/m0/s1
InChi Key
MSMRAGNKRYVTCX-LURJTMIESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $49

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    10 mg

    $93

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    50 mg

    $213

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    100 mg

    $400

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    Product Description

    N-acetyl-L-Cysteine ethyl ester is an esterified form of N-acetyl-L-cysteine (NAC; Item No. 20261). It has enhanced cell permeability in isolated perfused rat liver compared to NAC.1 N-acetyl-L-Cysteine ethyl ester (1 mM) prevents tert-butyl hydroperoxide-induced formation of methemoglobin in isolated human red blood cells. It increases glutathione levels in rat liver, kidney, heart, testis, and brain when administered at a dose of 50 mg/kg twice per day for two weeks. N-acetyl-L-Cysteine ethyl ester reduces increases in plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) levels induced by paracetamol (acetaminophen; Item No. 10024) in rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Giustarini, D., Milzani, A., Dalle-Donne, I., et al. N-Acetylcysteine ethyl ester (NACET): A novel lipophilic cell-permeable cysteine derivative with an unusual pharmacokinetic feature and remarkable antioxidant potential. Biochem. Pharmacol. 84(11), 1522-1533 (2012).