A dopamine receptor agonist
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Metabolite(s)
36328Piribedil N-oxide
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Piribedil

Item No. 30321

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-pyrimidine
CAS Number
3605-01-4
Molecular Formula
C16H18N4O2
Formula Weight
298.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10mg/mLDMF:PBS (pH 7.2) (1:6): 0.14mg/mLDMSO: 5mg/mLEthanol: 5mg/mL
λmax
242 nm
SMILES
N1(C2=NC=CC=N2)CCN(CC3=CC(OCO4)=C4C=C3)CC1
InChi Code
InChI=1S/C16H18N4O2/c1-4-17-16(18-5-1)20-8-6-19(7-9-20)11-13-2-3-14-15(10-13)22-12-21-14/h1-5,10H,6-9,11-12H2
InChi Key
OQDPVLVUJFGPGQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

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    Product Description

    Piribedil is a dopamine receptor agonist.1,2,3,4 It binds to dopamine D2, D3, and D4 receptors (IC50s = 1-1,000 nM in radioligand binding assays).1 Piribedil (1 and 10 mg/kg) enhances spontaneous object recognition in young adult rats and attenuates age-related memory impairments in the radial arm maze in mice.2 It reduces immobility time in the forced swim test in mice when administered at doses ranging from 0.63 to 10 mg/kg.3 Piribedil (0.3 mg/kg) decreases the number of premature and delayed responses in a response time test, indicating improved attentional function, in a rat model of Parkinson's disease induced by 6-OHDA (Item No. 25330) when administered in combination with L-DOPA (Item No. 13248).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cagnotto, A., Parotti, L., and Mennini, T. In vitro affinity of piribedil for dopamine D3 receptor subtypes, an autoradiographic study. Eur. J. Pharmacol. 313(1-2), 63-67 (1996).

    2. Marighetto, A., Valerio, S., Philippin, J.N., et al. Comparative effects of the dopaminergic agonists piribedil and bromocriptine in three different memory paradigms in rodents. J. Psychopharmacol. 22(5), 511-521 (2008).

    3. Brocco, M., Dekeyne, A., Papp, M., et al. Antidepressant-like properties of the anti-Parkinson agent, piribedil, in rodents: Mediation by dopamine D2 receptors. Behav. Pharmacol. 17(7), 559-572 (2006).

    4. Turle-Lorenzo, N., Maurin, B., Puma, C., et al. The dopamine agonist piribedil with L-DOPA improves attentional dysfunction: Relevance for Parkinson’s disease. J. Pharmacol. Exp. Ther. 319(2), 914-923 (2006).