A TRPM8 agonist
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WS-12

Item No. 30352

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)-cyclohexanecarboxamide
CAS Number
68489-09-8
Molecular Formula
C18H27NO2
Formula Weight
289.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 5 mg/mlEthanol: 5 mg/ml
λmax
251 nm
SMILES
C[C@@H]1CC[C@@H](C(C)C)[C@H](C(NC2=CC=C(OC)C=C2)=O)C1
InChi Code
InChI=1S/C18H27NO2/c1-12(2)16-10-5-13(3)11-17(16)18(20)19-14-6-8-15(21-4)9-7-14/h6-9,12-13,16-17H,5,10-11H2,1-4H3,(H,19,20)/t13-,16+,17-/m1/s1
InChi Key
HNSGVPAAXJJOPQ-XOKHGSTOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $95

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    10 mg

    $131

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    50 mg

    $510

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    100 mg

    $922

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    Product Description

    WS-12 is an agonist of transient receptor potential melastatin 8 (TRPM8).1 It induces currents in Xenopus oocytes expressing mouse TRPM8 (EC50 = 12 µM) and is selective for TRPM8 over transient receptor potential vanilloid 1-4 (TRPV1-4) and transient receptor potential ankyrin 1 (TRPA1) at 1 mM. WS-12 (6 nmol, i.c.v.) reduces nocifensive behavior induced by capsaicin (Item Nos. 92350 | 10010743) in wild-type, but not Trpm8-/-, mice.2 It induces analgesia in the hot plate test, an effect that can be reversed by the opioid receptor antagonist naloxone, in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sherkheli, M.A., Gisselmann, G., Vogt-Eisele, A.K., et al. Menthol derivative WS-12 selectively activates transient receptor potential melastatin-8 (TRPM8) ion channels. Pak. J. Pharm. Sci. 21(4), 370-378 (2008).

    2. Liu, B., Fan, L., Balakrishna, S., et al. TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain. Pain 2013, (2013).