A sesquiterpene with diverse biological activities
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Isomer(s)
26849Curcumol
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Curdione

Item No. 30365

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3S,6E,10S)-6,10-dimethyl-3-(1-methylethyl)-6-cyclodecene-1,4-dione
CAS Number
13657-68-6
Synonyms
  • (+)-Curdione
Molecular Formula
C15H24O2
Formula Weight
236.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
SMILES
O=C1C/C(C)=C/CC[C@H](C)C(C[C@H]1C(C)C)=O
InChi Code
InChI=1S/C15H24O2/c1-10(2)13-9-14(16)12(4)7-5-6-11(3)8-15(13)17/h6,10,12-13H,5,7-9H2,1-4H3/b11-6+/t12-,13-/m0/s1
InChi Key
KDPFMRXIVDLQKX-NHFJXKHHSA-N
Origin
Plant/Curcuma zedoaria
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    500 µg

    $98

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    1 mg

    $185

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    5 mg

    $627

    Add
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    Product Description

    Curdione is a sesquiterpene that has been found in C. wenyujin and has diverse biological activities. It reduces the cytopathic effect of influenza A in MDCK cells (IC50 = 28.32 μM).1 Curdione (100 μM) inhibits thrombin-induced aggregation, AMP-activated protein kinase (AMPK) and integrin αIIbβ3 phosphorylation, and increases in talin and vinculin levels in washed platelets.2 It inhibits prostaglandin E2 (PGE2; Item No. 14010) production in LPS-stimulated RAW 264.7 macrophages (IC50 = 1.12 μM).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dong, J.-Y., Ma, X.-Y., Cai, X.-Q., et al. Sesquiterpenoids from Curcuma wenyujin with anti-influenza viral activities. Phytochemistry 85, 122-128 (2013).

    2. Hui, F., Beibei, G., Yingli, Z., et al. Curdione inhibits thrombin-induced platelet aggregation via regulating the AMP-activated protein kinase-vinculin/talin-integrin αIIbβ3 sign pathway. Phytomedicine 61, 152859 (2019).

    3. Oh, O.-J., Min, H.-Y., and Lee, S.K. Inhibition of inducible prostaglandin E2 production and cyclooxygenase-2 expression by curdione from Curcuma zedoaria. Arch. Pharm. Res. 30(10), 1236-1239 (2007).