A sesquiterpene alcohol with diverse biological activities
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Isomer(s)
30365Curdione
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Curcumol

Item No. 26849

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3S,3aS,5S,6R,8aS)-octahydro-3-methyl-8-methylene-5-(1-methylethyl)-6H-3a,6-epoxyazulen-6-ol
CAS Number
4871-97-0
Synonyms
  • (−)-Curcumol
Molecular Formula
C15H24O2
Formula Weight
236.4
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 10 mg/ml
SMILES
C=C1C[C@]2(O)[C@H](C(C)C)C[C@@]3(O2)[C@@]1([H])CC[C@@H]3C
InChi Code
InChI=1S/C15H24O2/c1-9(2)13-8-14-11(4)5-6-12(14)10(3)7-15(13,16)17-14/h9,11-13,16H,3,5-8H2,1-2,4H3/t11-,12-,13-,14-,15+/m0/s1
InChi Key
QRMPRVXWPCLVNI-YYFQZIEXSA-N
Origin
Plant/Curcuma zedoaria
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $120

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    25 mg

    $270

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    50 mg

    $421

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    100 mg

    $720

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    Product Description

    Curcumol is a sesquiterpene alcohol that has been found in Curcumae oil and has diverse biological activities.1,2,3,4 It is a positive allosteric modulator (PAM) of GABAA receptors that potentiates GABA-induced currents in the presence of the benzodiazepine GABA agonist diazepam, but not the GABAA PAM (–)-menthol, in mouse hippocampal neurons.1 Curcumol (1-200 μg/ml) reduces activation of proinflammatory NF-κB and profibrotic TGF-β1/SMAD signaling pathways in RAW 264.7 cells stimulated with cigarette smoke extract.2 It inhibits proliferation of and induces apoptosis in LoVo and SW480 colorectal cancer cells in a concentration-dependent manner.3 In vivo, curcumol (20-80 mg/kg) reduces tumor volume in a LoVo mouse xenograft model. Curcumol also increases the rate of wound closure in rats with diabetes induced by streptozotocin (Item No. 13104).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, Y.-M., Fan, H.-R., Ding, J., et al. Curcumol allosterically modulates GABA(A) receptors in a manner distinct from benzodiazepines. Sci. Rep. 7:46654, (2017).

    2. Li, N., Liu, T.-H., Yu, J.-Z., et al. Curcumin and curcumol inhibit NF-κB and TGF-β1/Smads signaling pathways in CSE-treated RAW246.7 cells. Evid. Based Complement. Alternat. Med. 3035125 (2019).

    3. Wang, J., Huang, F., Bai, Z., et al. Curcumol inhibits growth and induces apoptosis of colorectal cancer LoVo cell line via IGF-1R and p38 MAPK pathway. Int. J. Mol. Sci. 16(8), 19851-19867 (2015).

    4. Zhou, J., Ni, M., Liu, X., et al. Curcumol promotes vascular endothelial growth factor (VEGF)-mediated diabetic wound healing in streptozotocin-induced hyperglycemic rats. Med. Sci. Monit. 23, 555-562 (2017).