An excitatory neurotransmitter
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Enantiomer(s)
31503D-Glutamic Acid
Isomer(s)
14581NMDA
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L-Glutamic Acid (ammonium salt)

Item No. 30377

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-glutamic acid, monoammonium salt
CAS Number
7558-63-6
Synonyms
  • Glutamic Acid
Molecular Formula
C5H9NO4 • NH3
Formula Weight
164.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
OC([C@@H](N)CCC(O)=O)=O.N
InChi Code
InChI=1S/C5H9NO4.H3N/c6-3(5(9)10)1-2-4(7)8;/h3H,1-2,6H2,(H,7,8)(H,9,10);1H3/t3-;/m0./s1
InChi Key
PHKGGXPMPXXISP-DFWYDOINSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 g

    $61

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    10 g

    $104

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    25 g

    $227

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    Product Description

    L-Glutamic acid is a non-essential amino acid and the primary excitatory neurotransmitter in the CNS.1 It acts on ionotropic and metabotropic receptors to induce excitatory synaptic transmission and has roles in synaptic plasticity. Excessive release of L-glutamic acid induces excitotoxicity that is associated with various human diseases, including amyotrophic lateral sclerosis (ALS), stroke, Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease.2 Excessive L-glutamic acid release, in its protonated glutamate form, also occurs during seizure activity and contributes to epileptogenesis and seizure-induced brain damage.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Garattini, S. Glutamic acid, twenty years later. J. Nutr. 130(4S Suppl), 901S-909S (2000).

    2. Greenamyre, J.T. The role of glutamate in neurotransmission and in neurologic disease. Arch. Neurol. 43(10), 1058-1063 (1986).

    3. Barker-Haliski, M., and White, H.S. Glutamatergic mechanisms associated with seizures and epilepsy. Cold Spring Harb. Perspect. Med. 5(8), a022863 (2015).

    Product Citations

    Rubio-Atonal, L.F., Chang, J., Jacquemyn, J., et al. Glutamate decreases oxidative stress and lipid droplet formation in astrocytes. J. Cell Sci. 138(19), jcs263983 (2025).