An inhibitor of ASK1
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CAY10756

Item No. 30382

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-methoxy-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-1-(2-pyrazinyl)-1H-pyrazole-4-carboxamide
CAS Number
2411382-24-4
Molecular Formula
C19H19N9O2
Formula Weight
405.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Chloroform: 10 mg/ml
λmax
275, 318 nm
SMILES
O=C(C1=CN(C2=NC=CN=C2)N=C1OC)NC3=CC=CC(C4=NN=CN4C(C)C)=N3
InChi Code
InChI=1S/C19H19N9O2/c1-12(2)27-11-22-25-17(27)14-5-4-6-15(23-14)24-18(29)13-10-28(26-19(13)30-3)16-9-20-7-8-21-16/h4-12H,1-3H3,(H,23,24,29)
InChi Key
FTPVMITWJIXRGQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $54

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    1 mg

    $96

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    5 mg

    $367

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    Product Description

    CAY10756 is a brain-penetrant inhibitor of apoptosis signal-regulating kinase 1 (ASK1; IC50 = 21 nM).1 It inhibits autophosphorylation of ASK1 in HEK293T cells (IC50 = 138 nM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xin, Z., Himmelbauer, K., Jones, J.H., et al. Discovery of CNS-penetrant apoptosis signal-regulating kinase 1 (ASK1) inhibitors. ACS Med. Chem. Lett. 11(4), 485-490 (2020).