A PARP inhibitor
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m-Methoxybenzamide

Item No. 30451

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-methoxy-benzamide
CAS Number
5813-86-5
Synonyms
  • m-Anisamide
  • meta-Methoxybenzamide
  • NSC 28589
  • NSC 209527
Molecular Formula
C8H9NO2
Formula Weight
151.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.50 mg/mlEthanol: 1 mg/ml
SMILES
COC1=CC=CC(C(N)=O)=C1
InChi Code
InChI=1S/C8H9NO2/c1-11-7-4-2-3-6(5-7)8(9)10/h2-5H,1H3,(H2,9,10)
InChi Key
VKPLPDIMEREJJF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $69

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    10 g

    $127

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    25 g

    $297

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    Product Description

    m-Methoxybenzamide is an inhibitor of poly(ADP-ribose) polymerase (PARP; Ki = <2 µM).1 It also inhibits human placental ADP ribosyl transferase activity by 93% when used at a concentration of 100 µM.2 m-Methoxybenzamide (100, 200, and 300 mg/kg) increases the pain threshold in the paw pinch test in rats.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Purnell, M.R., and Whish, W.J. Novel inhibitors of poly(ADP-ribose) synthetase. Biochem. J. 185(3), 775-777 (1980).

    2. Burtscher, H.J., Auer, B., Klocker, H., et al. Isolation of ADP-ribosyltransferase by affinity chromatography. Anal. Biochem. 152(2), 285-290 (1986).

    3. Sanders, R., Dill, R.E., Dorris, R.L., et al. Analgesic effects of 3-methoxybenzamide in rats. J. Pharm. Pharmacol. 41(4), 268-269 (1989).