A heterocyclic building block
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6-Hydroxypyridin-3-ylboronic Acid

Item No. 30492

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
B-(1,6-dihydro-6-oxo-3-pyridinyl)-boronic acid
CAS Number
903899-13-8
Molecular Formula
C5H6BNO3
Formula Weight
138.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:5): 0.16 mg/mlEthanol: 1 mg/ml
λmax
243, 300 nm
SMILES
O=C1C=CC(B(O)O)=CN1
InChi Code
InChI=1S/C5H6BNO3/c8-5-2-1-4(3-7-5)6(9)10/h1-3,9-10H,(H,7,8)
InChi Key
YUOLAYZNDYRBEZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $69

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    Product Description

    6-Hydroxypyridin-3-ylboronic acid is a heterocyclic building block.1,2 It has been used in the synthesis of non-nucleoside inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase nonstructural protein 5B (NS5B).1 6-Hydroxypyridin-3-ylboronic acid has also been used in the synthesis of mammalian target of rapamycin (mTOR) inhibitors.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hendricks, R.T., Spencer, S.R., Blake, J.F., et al. 3-Hydroxyisoquinolines as inhibitors of HCV NS5b RNA-dependent RNA polymerase. Bioorg. Med. Chem. Lett. 19(2), 410-414 (2009).

    2. Verheijen, J.C., Richard, D.J., Curran, K., et al. Discovery of 4-morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as highly potent and sselective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): Optimization of the 6-aryl substituent. J. Med. Chem. 52(24), 8010-8024 (2009).