For immunochemical detection of ACE2
Related Products
Alternative(s)
33336ACE2 Polyclonal Antibody
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ACE2 (human) Monoclonal Antibody - Biotinylated (Clone AC18F)

Item No. 30583

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • ACE-related Carboxypeptidase
  • ACEH
  • Angiotensin-converting Enzyme 2
  • Angiotensin-converting Enzyme Homolog
  • Metalloprotease MPROT15
Immunogen
Recombinant human ACE2
Clone Designation
AC18F
Formulation (Request formulation change)
50 µg of Protein G-purified monoclonal antibody
Storage Buffer
0.2 µm-filtered solution in PBS, pH 7.4
Host
Mouse
Isotype
IgG1κ
Applications
ELISA, FC, and WB
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    50 µg

    $356

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    Cayman Chemical
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    Product Description

    Angiotensin-converting enzyme 2 (ACE2) is a carboxypeptidase and homolog of ACE1 that is encoded by ACE2 in humans.1,2 It is a type I transmembrane protein composed of a cytoplasmic tail and an extracellular domain containing an HEMGH motif, characteristic of zinc-metallopeptidases, which exhibits carboxymonopeptidase activity.1 ACE2 is expressed in vascular endothelial cells where it catalyzes the conversion of angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to the vasodilatory peptide angiotensin 1-7 to regulate systemic blood pressure.1,2 It is also expressed in the epithelial cells of the kidney, heart, lung, small intestine, and liver and has roles in fluid homeostasis, cardiac contractility, and amino acid absorption, as well as the prevention of pulmonary fibrosis and hypertension. ACE2 also acts as a functional receptor for severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 to facilitate viral entry into host cells.3,4 Cayman's ACE2 (human) Monoclonal Antibody-Biotinylated (Clone AC18F) can be used for ELISA, flow cytometry (FC), and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Perlot, T., and Penninger, J.M. ACE2 – From the renin-angiotensin system to gut microbiota and malnutrition. Microbes Infect. 15(13), 866-873 (2013).

    2. Santos, R.A.S., Sampaio, W.O., Alzamora, A.C., et al. The ACE2/angiotensin-(1-7)/MAS axis of the renin-angiotensin system: Focus on angiotensin-(1-7). Physiol. Rev. 98(1), 505-553 (2018).

    3. Hoffmann, M., Kleine-Weber, H., Schroeder, S., et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell 181(2), 271-280 (2020).

    4. Gurwitz, D. Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics. Drug Dev. Res. 81(5), 537-540 (2020).