For immunochemical detection of ACE2
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ACE2 Polyclonal Antibody

Item No. 33336

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • ACE-related Carboxypeptidase
  • ACEH
  • Angiotensin-converting Enzyme 2
  • Angiotensin-converting Enzyme Homolog
  • Metalloprotease MPROT15
Immunogen
Recombinant full-length human ACE2
MW
~93 kDa
Formulation (Request formulation change)
500 µg of protein A-purified polyclonal antibody
Storage Buffer
PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide
Host
Rabbit
Applications
ELISA, WB
Cross Reactivity
(+) ACE2
Species Reactivity
(+) Human(+) Mouse
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $347

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    Cayman Chemical
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    Product Description

    Angiotensin-converting enzyme 2 (ACE2) is a carboxypeptidase and homolog of ACE1 that is encoded by ACE2 in humans.1,2 It is a type I transmembrane protein composed of a cytoplasmic tail and an extracellular domain containing an HEMGH motif, characteristic of zinc-metallopeptidases, which exhibits carboxymonopeptidase activity.1 ACE2 is expressed in vascular endothelial cells where it catalyzes the conversion of angiotensin II to the vasodilatory peptide angiotensin 1-7 to regulate systemic blood pressure and angiotensin I to angiotensin 1-9, a peptide that counter-regulates the function of angiotensin II.1,2,3 It is also expressed in the epithelial cells of the kidney, heart, lung, small intestine, and liver and has roles in fluid homeostasis, cardiac contractility, and amino acid absorption, as well as the prevention of pulmonary fibrosis and hypertension. ACE2 also acts as a functional receptor for severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 to facilitate viral entry into host cells.4,5 Cayman’s ACE2 Polyclonal Antibody can be used for ELISA and Western blot (WB) applications. The antibody recognizes ACE2 at approximately 93 kDa from human and mouse samples.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Perlot, T., and Penninger, J.M. ACE2 – From the renin-angiotensin system to gut microbiota and malnutrition. Microbes Infect. 15(13), 866-873 (2013).

    2. Santos, R.A.S., Sampaio, W.O., Alzamora, A.C., et al. The ACE2/angiotensin-(1-7)/MAS axis of the renin-angiotensin system: Focus on angiotensin-(1-7). Physiol. Rev. 98(1), 505-553 (2018).

    3. Ocaranza, M.P., Moya, J., Barrientos, V., et al. Angiotensin-(1—9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin converting enzyme/Ang II axis. J. Hypertens. 32(4), 771-783 (2014).

    4. Hoffmann, M., Kleine-Weber, H., Schroeder, S., et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell 181(2), 271-280 (2020).

    5. Gurwitz, D. Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics. Drug Dev. Res. 81(5), 537-540 (2020).