A liver-targeted prodrug of MB-07344
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MB-07811

Item No. 30670

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[4-[[(2R,4S)-4-(3-chlorophenyl)-2-oxido-1,3,2-dioxaphosphorinan-2-yl]methoxy]-2,6-dimethylphenyl]methyl]-2-(1-methylethyl)-phenol
CAS Number
852948-13-1
Synonyms
  • VK-2809
Molecular Formula
C28H32ClO5P
Formula Weight
515.0
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleDMSO: Soluble
SMILES
OC1=C(C(C)C)C=C(C=C1)CC2=C(C=C(C=C2C)OC[P@]3(OCC[C@H](O3)C4=CC=CC(Cl)=C4)=O)C
InChi Code
InChI=1S/C28H32ClO5P/c1-18(2)25-14-21(8-9-27(25)30)15-26-19(3)12-24(13-20(26)4)32-17-35(31)33-11-10-28(34-35)22-6-5-7-23(29)16-22/h5-9,12-14,16,18,28,30H,10-11,15,17H2,1-4H3/t28-,35+/m0/s1
InChi Key
LGGPZDRLTDGYSQ-JADSYQMUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $39

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    5 mg

    $154

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    10 mg

    $270

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    25 mg

    $578

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    MB-07811 is a liver-targeted prodrug form of the thyroid hormone receptor β (TRβ) agonist MB-07344.1 It is stable in extrahepatic tissues and converted to MB-07344 in the liver. MB-07811 binds to TRα1 and TRβ1 with Ki values of 12.5 and 14.6 µM, respectively. Oral administration of MB-07811 reduces plasma cholesterol levels (ED50 = 0.48 mg/kg) in a cholesterol-fed rat (CFR) model. It also reduces hepatic steatosis, as well as plasma levels of cholesterol, in Zucker diabetic fatty rats in a model of non-alcoholic fatty liver disease (NAFLD) when administered at a dose of 5 mg/kg per day.2 MB-07811 (10 mg/kg) reverses hepatic steatosis, reducing total hepatic lipids without decreasing body weight, in a mouse model of diet-induced obesity.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Boyer, S.H., Jiang, H., Jacintho, J.D., et al. Synthesis and biological evaluation of a series of liver-selective phosphonic acid thyroid hormone receptor agonists and their prodrugs. J. Med. Chem. 51(22), 7075-7093 (2008).

    2. Cable, E.E., Finn, P.D., Stebbins, J.W., et al. Reduction of hepatic steatosis in rats and mice after treatment with a liver-targeted thyroid hormone receptor agonist. Hepatology 49(2), 407-417 (2009).