An inhibitor of VAP-1
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BI-1467335

Item No. 30672

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[(2E)-2-(aminomethyl)-3-fluoro-2-propen-1-yl]oxy]-N-(1,1-dimethylethyl)-benzamide, monohydrochloride
CAS Number
1478364-68-9
Synonyms
  • PXS-4728A
Molecular Formula
C15H21FN2O2 • HCl
Formula Weight
316.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleWater: Soluble
SMILES
O=C(NC(C)(C)C)C1=CC=C(OC/C(CN)=C/F)C=C1.Cl
InChi Code
InChI=1S/C15H21FN2O2.ClH/c1-15(2,3)18-14(19)12-4-6-13(7-5-12)20-10-11(8-16)9-17;/h4-8H,9-10,17H2,1-3H3,(H,18,19);1H/b11-8+;
InChi Key
AEMZEDNMNLIDSL-YGCVIUNWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $32

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    5 mg

    $128

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    10 mg

    $208

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    25 mg

    $439

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    BI-1467335 is an inhibitor of vascular adhesion protein-1 (VAP-1; IC50 = <100 nM), also known as semicarbazide-sensitive amine oxidase (SSAO), an enzyme with roles in leukocyte adhesion and transmigration.1 It is selective for VAP-1 over monoamine oxidase B (MAO-B) and diamine oxidase (DAO; IC50s = >1,000 and >10,000 nM, respectively). Oral administration of BI-1467335 (10 mg/kg per day) reduces plasma total cholesterol, LDL, and glucose levels, as well as decreases the recruitment of macrophages to atherosclerotic lesions and the area of atherosclerotic plaques, in a cholesterol-fed rabbit model.2 It reduces neutrophil lung infiltration induced by K. pneumoniae in mice when administered at a dose of 6 mg/kg.3 It also reduces airway hyperreactivity in a mouse model of rhinovirus-exacerbated allergy-induced asthma.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

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