An NMDA receptor antagonist
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L-701,324

Item No. 30687

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-chloro-4-hydroxy-3-(3-phenoxyphenyl)-2(1H)-quinolinone
CAS Number
142326-59-8
Molecular Formula
C21H14ClNO3
Formula Weight
363.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
λmax
226 nm
SMILES
ClC1=CC=C2C(NC(C(C3=CC(OC4=CC=CC=C4)=CC=C3)=C2O)=O)=C1
InChi Code
InChI=1S/C21H14ClNO3/c22-14-9-10-17-18(12-14)23-21(25)19(20(17)24)13-5-4-8-16(11-13)26-15-6-2-1-3-7-15/h1-12H,(H2,23,24,25)
InChi Key
FLVRDMUHUXVRET-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $103

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    50 mg

    $378

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    100 mg

    $553

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    Product Description

    L-701,324 is an NMDA receptor antagonist.1 It inhibits NMDA-induced currents in rat cortical neurons (Ki = 5.4 nM). L-701,324 inhibits seizures induced by N-methyl-DL-aspartate, pentylenetetrazole (PTZ; Item No. 18682), or electroshock, as well as audiogenic seizures in mice (ED50s = 3.5, 2.8, 1.4, and 0.96 mg/kg, respectively).2 It reduces the number of audiogenic seizures in a rat model of ethanol-induced withdrawal seizures when administered at a dose of 5 mg/kg.3 L-701,324 (2.5 and 5 mg/kg) reduces amphetamine-induced hyperactivity in rats.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Priestley, T., Laughton, P., Macaulay, A.J., et al. Electrophysiological characterisation of the antagonist properties of two novel NMDA receptor glycine site antagonists, L-695,902 and L-701,324. Neuropharmacology 35(11), 1573-1581 (1996).

    2. Bristow, L.J., Hutson, P.H., Kulagowski, J.J., et al. Anticonvulsant and behavioral profile of L-701,324, a potent, orally active antagonist at the glycine modulatory site on the N-methyl-D-aspartate receptor complex. J. Pharmacol. Exp. Ther. 279(2), 492-501 (1996).

    3. Kotlinska, J., and Liljequist, S. Oral administration of glycine and polyamine receptor antagonists blocks ethanol withdrawal seizures. Psychopharmacology (Berl) 127(3), 238-244 (1996).

    4. Bristow, L.J., Flatman, K.L., Hutson, P.H., et al. The atypical neuroleptic profile of the glycine/N-methyl-D-aspartate receptor antagonist, L-701,324, in rodents. J. Pharmacol. Exp. Ther. 277(2), 578-585 (1996).