A Nur77 antagonist
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C-DIM8

Item No. 30694

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(di-1H-indol-3-ylmethyl)-phenol
CAS Number
151358-47-3
Synonyms
  • DIM-C-pPhOH
  • 1,1-bis-(3’-indolyl)-1-(p-hydroxyphenyl)methane
Molecular Formula
C23H18N2O
Formula Weight
338.4
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMF:PBS (pH 7.2) (1:6): 0.14 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/ml
λmax
212, 262 nm
SMILES
OC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1
InChi Code
InChI=1S/C23H18N2O/c26-16-11-9-15(10-12-16)23(19-13-24-21-7-3-1-5-17(19)21)20-14-25-22-8-4-2-6-18(20)22/h1-14,23-26H
InChi Key
QCPDFNWJBQMXLI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Cayman Chemical
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    Product Description

    C-DIM8 is a para-phenyl-substituted diindolylmethane (C-DIM) and an antagonist of the orphan receptor nuclear receptor-related protein 77 (Nur77).1 It inhibits reporter gene expression induced by the Nur77 agonist C-DIM5 (Item No. 27980) in PANC-28 cells when used at a concentration of 20 µM. C-DIM8 (10, 15, and 20 µM) reduces expression of BIRC5, the gene encoding survivin, in PANC-1 pancreatic cancer cells.2 In vivo, C-DIM8 (30 mg/kg) induces tumor cell apoptosis and reduces tumor volume in an L3.6pl pancreatic carcinoma mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chintharlapalli, S., Burghardt, R., Papineni, S., et al. Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways. The Journal of Biological Chemisty 280(26), 24903-24914 (2005).

    2. Lee, S.-O., Abdelrahim, M., Yoon, K., et al. Inactivation of the orphan nuclear receptor TR3/Nur77 inhibits pancreatic cancer cell and tumor growth. Cancer Res. 70(17), 6824-6836 (2010).