A sesquiterpene with diverse biological activities
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Isocurcumenol

Item No. 30710

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
octahydro-3S-methyl-8aS-methylene-5-(1-methylethylidene)-6H-3aS,6-epoxyazulen-6R-ol
CAS Number
24063-71-6
Synonyms
  • (+)-Isocurcumenol
Molecular Formula
C15H22O2
Formula Weight
234.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlEthanol: slightly soluble
SMILES
C=C([C@@]1([H])[C@]([C@@H](C)CC1)(O2)C/3)C[C@]2(O)C3=C(C)/C
InChi Code
InChI=1S/C15H22O2/c1-9(2)13-8-14-11(4)5-6-12(14)10(3)7-15(13,16)17-14/h11-12,16H,3,5-8H2,1-2,4H3/t11-,12-,14-,15+/m0/s1
InChi Key
DEBDFZGNZTYPMF-NZBPQXDJSA-N
Origin
Plant/Curcuma phaeocaulis
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $213

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    10 mg

    $376

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    25 mg

    $762

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    Product Description

    Isocurcumenol is a sesquiterpene that has been found in C. zedoaria rhizomes and has diverse biological activities.1,2,3 Isocurcumenol inhibits LPS-induced production of nitric oxide (NO) in isolated mouse peritoneal macrophages.3 It reduces LPS/D-galactosamine-induced increases in serum levels of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) in a mouse model of liver injury when administered at a dose of 50 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, C., Long, L., Zhang, F., et al. Antifungal activity, main active components and mechanism of Curcuma longa extract against Fusarium graminearum. PLoS One 13(3), e0194284 (2018).

    2. Lakshmi, S., Padmaja, G., and Remani, P. Antitumour effects of isocurcumenol isolated from Curcuma zedoaria rhizomes on human and murine cancer cells. Int. J. Med. Chem. 253962 (2011).

    3. Matsuda, H., Ninomiya, K., Morikawa, T., et al. Inhibitory effect and action mechanism of sesquiterpenes from zedoariae rhizoma on D-galactosamine/lipopolysaccharide-induced liver injury. Bioorg. Med. Chem. Lett. 8(4), 339-344 (1998).