A 5-HT receptor antagonist
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Cinanserin (hydrochloride)

Item No. 30729

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-[[3-(dimethylamino)propyl]thio]phenyl]-3-phenyl-2-propenamide, monohydrochloride
CAS Number
54-84-2
Synonyms
  • SQ 10,643
Molecular Formula
C20H24N2OS • HCl
Formula Weight
376.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O=C(NC1=C(SCCCN(C)C)C=CC=C1)/C=C/C2=CC=CC=C2.Cl
InChi Code
InChI=1S/C20H24N2OS.ClH/c1-22(2)15-8-16-24-19-12-7-6-11-18(19)21-20(23)14-13-17-9-4-3-5-10-17;/h3-7,9-14H,8,15-16H2,1-2H3,(H,21,23);1H/b14-13+;
InChi Key
LXGJPDKYMJJWRB-IERUDJENSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $103

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    10 mg

    $173

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    Cayman Chemical
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    Product Description

    Cinanserin is a serotonin (5-HT) receptor antagonist.1,2 It inhibits 5-HT-induced effects on isolated rat uterus but not guinea pig ileum.1 Cinanserin inhibits 5-HT-induced gross excitation, gastric mucosal erosion, and anaphylactoid edema in mice and rats. Cinanserin (12 and 36 mg/kg, i.p.) impairs acquisition of a running response in rats trained for food reward.2 It inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) 3C-like proteinase (3CLpro; IC50 = 5 µM) and reduces SARS-CoV viral RNA levels in infected BHK-Rep-1 cells (IC50s = 19-34 µM).3 It also inhibits viral replication of murine hepatitis virus (MHV) in CCL-9.1 murine liver epithelial cells (IC50 = 31.25 µg/ml).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rubin, B., Piala, J.J., Burke, J.C., et al. A new, potent, and specific serotonin inhibitor (SQ 10,643) 2' -(3 - dimethylaminopropylthio)cinnamanilide hydrochloride: Antiserotonin activity on uterus and on gastrointestinal, vascular, and respiratory systems of animals. Arch. Int. Pharmacodyn. Ther. 152, 132-143 (1964).

    2. Rosen, A.J., and Cohen, M.E. The effects of cinanserin, a potent serotonin antagonist, on the acquisition of a running response in the rat. Neuropharmacology 12(6), 501-508 (1973).

    3. Chen, L., Gui, C., Luo, X., et al. Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro. J. Virol. 79(11), 7095-7103 (2005).

    4. K.H., C., Phoon, M.C., Putti, T., et al. Evaluation of antiviral activities of Houttuynia cordata Thunb. extract, quercetin, quercetrin and cinanserin on murine coronavirus and dengue virus infection. Asian Pac. J. Trop. Med. 9(1), 1-7 (2016).