A TrxR inhibitor
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Aurothioglucose (hydrate)

Item No. 30732

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Gold Thioglucose
Molecular Formula
C6H11AuO5S • XH2O
Formula Weight
392.2
Purity
≥80%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
O[C@@H]([C@@H]1O)[C@]([OH][Au+][S-]2)([H])C2O[C@@H]1CO.O
InChi Code
InChI=1S/C6H12O5S.Au.H2O/c7-1-2-3(8)4(9)5(10)6(12)11-2;;/h2-10,12H,1H2;;1H2/q;+1;/p-1/t2-,3-,4+,5-,6?;;/m1../s1
InChi Key
SGVIEHTYEMEDRR-DUMCKRSRSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $82

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    5 mg

    $222

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    10 mg

    $403

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    25 mg

    $703

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Aurothioglucose is an inhibitor of thioredoxin reductase (TrxR; IC50 = 0.065 µM for the human placental enzyme).1 It is selective for TrxR over glutathione reductase and glutathione peroxidase (GPX; IC50s = >100 and 80 µM, respectively). Aurothioglucose (100 µM) inhibits IL-1β-induced production of IL-6 and IL-8 in isolated human rheumatoid synovial fibroblasts.2 It reduces HIV-1 replication induced by TNF-α in OM10.1 cells latently infected with HIV-1 when used at concentrations of 10 and 25 µM.3 Aurothioglucose (25 mg/kg) improves survival in a mouse model of acute respiratory distress syndrome (ARDS) induced by LPS and hyperoxia.4 It induces obesity and increases food intake and blood glucose levels in genetically diabetic KK mice.5 Formulations containing aurothioglucose have previously been used in the treatment of rheumatoid arthritis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gromer, S., Arscott, L.D., Williams, C.H., Jr., et al. Human placenta thioredoxin reductase. Isolation of the selenoenzyme, steady kinetics, and inhibition by therapeutic gold compounds. The Journal of Biological Chemisty 273(32), 20096-20101 (1998).

    2. Yoshida, S., Kato, T., Sakurada, S., et al. Inhibition of IL-6 and IL-8 induction from cultured rheumatoid synovial fibroblasts by treatment with aurothioglucose. Int. Immunol. 11(2), 151-158 (1999).

    3. Traber, K.E., Okamoto, H., Kurono, C., et al. Anti-rheumatic compound aurothioglucose inhibits tumor necrosis factor-α-induced HIV-1 replication in latently infected OM10.1 and Ach2 cells. Int. Immunol. 11(2), 143-150 (1999).

    4. Britt, R.D., Jr., Velten, M., Locy, M.L., et al. The thioredoxin reductase-1 inhibitor aurothioglucose attenuates lung injury and improves survival in a murine model of acute respiratory distress syndrome. Antioxid. Redox Signal. 20(17), 2681-2691 (2014).

    5. Matsuo, T., and Shino, A. Induction of diabetic alterations by goldthioglucose-obesity in KK,ICR and C57BL mice. Diabetologia 8(6), 391-397 (1972).