A precursor and metabolite of cortisol
Related Products
Parent Compound(s)
20739Hydrocortisone
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Cortisone

Item No. 30763

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
17,21-dihydroxy-pregn-4-ene-3,11,20-trione
CAS Number
53-06-5
Synonyms
  • 17α-hydroxy-11-Dehydrocorticosterone
  • Kendall’s Compound E
  • 4-Pregnene-17α,21-diol-3,11,20-trione
  • Reichstein’s Substance Fa
Molecular Formula
C21H28O5
Formula Weight
360.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml
λmax
238 nm
SMILES
[H][C@]12[C@@]([C@@](CC[C@]3(O)C(CO)=O)([H])[C@]3(C)CC2=O)([H])CCC4=CC(CC[C@@]41C)=O
InChi Code
InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1
InChi Key
MFYSYFVPBJMHGN-ZPOLXVRWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $44

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    1 g

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    5 g

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    Product Description

    Cortisone is a glucocorticoid receptor-inert precursor and metabolite of the glucocorticoid cortisol (hydrocortisone; Item No. 20739).1,2 Cortisone is converted to glucocorticoid receptor-active cortisol by 11β-hydroxysteroid dehydrogenase (11β-HSD1) and is regenerated by metabolism of cortisol by 11β-HSD2 in vivo.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dammann, C., Stapelfeld, C., and Maser, E. Expression and activity of the cortisol-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 is tissue and species-specific. Chem. Biol. Interact. 303, 57-61 (2019).

    2. Viglietti, A.I.P., Giambartolomei, G.H., and Delpino, M.V. Endocrine modulation of Brucella abortus-infected osteocytes function and osteoclastogenesis via modulation of RANKL/OPG. Microbes Infect. 21(7), 287-295 (2019).