A ROCK inhibitor
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ZINC00881524

Item No. 30788

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4,5-dihydronaphtho[1,2-d]thiazol-2-yl)-3,4-dimethoxy-benzeneacetamide
CAS Number
557782-81-7
Molecular Formula
C21H20N2O3S
Formula Weight
380.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
λmax
232, 282 nm
SMILES
COC1=C(OC)C=CC(CC(NC2=NC(C(C=CC=C3)=C3CC4)=C4S2)=O)=C1
InChi Code
InChI=1S/C21H20N2O3S/c1-25-16-9-7-13(11-17(16)26-2)12-19(24)22-21-23-20-15-6-4-3-5-14(15)8-10-18(20)27-21/h3-7,9,11H,8,10,12H2,1-2H3,(H,22,23,24)
InChi Key
DQNMDJGZWFZNHS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $49

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    10 mg

    $93

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    50 mg

    $423

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    100 mg

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    Product Description

    ZINC00881524 is a Rho-associated kinase (ROCK) inhibitor.1 It decreases levels of ROCK1 in T47D and CAMA-1 breast cancer cells. ZINC00881524 decreases proliferation of T47D and CAMA-1 cells when used in combination with CNN1 knockdown.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, Z., Li, T.-E., Chen, M., et al. miR-106b-5p contributes to the lung metastasis of breast cancer via targeting CNN1 and regulating Rho/ROCK1 pathway. Aging (Albany NY) 12(2), 1867-1887 (2020).