A short-chain acylcarnitine
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Labeled Version(s)
265722-Methylbutyryl-L-carnitine-d3 (chloride)
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2-Methylbutyryl-L-carnitine

Item No. 30818

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R)-3-carboxy-N,N,N-trimethyl-2-(2-methyl-1-oxobutoxy)-1-propanaminium, inner salt
CAS Number
256928-75-3
Synonyms
  • C5:0 Carnitine
  • CAR 5:0
  • L-Carnitine 2-methylbutyroyl ester
  • L-Carnitine 2-methylbutyryl ester
  • 2-Methylbutyroylcarnitine
  • 2-Methylbutyrylcarnitine
Molecular Formula
C12H23NO4
Formula Weight
245.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: Sparingly soluble: 1-10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
SMILES
CCC(C)C(O[C@@H](C[N+](C)(C)C)CC([O-])=O)=O
InChi Code
InChI=1S/C12H23NO4/c1-6-9(2)12(16)17-10(7-11(14)15)8-13(3,4)5/h9-10H,6-8H2,1-5H3/t9?,10-/m1/s1
InChi Key
IHCPDBBYTYJYIL-QVDQXJPCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

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    Product Description

    2-Methylbutyryl-L-carnitine is a naturally occurring acylcarnitine that is produced via L-isoleucine metabolism.1 2-Methylbutyryl-L-carnitine levels decrease in OVCAR-8 and adriamycin-resistant OVCAR-8 ovarian cancer cells undergoing ferroptosis induced by erastin (Item No. 17754).2 Plasma levels of 2-methylbutyryl-L-carnitine are elevated in patients with non-alcoholic steatohepatitis (NASH).3 Elevated levels of 2-methylbutyryl-L-carnitine are associated with 2-methylbutyryl-CoA dehydrogenase deficiency (2-MBCDD), also known as short/branched chain acyl-CoA dehydrogenase (SBCAD) deficiency.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gibson, K.M., Burlingame, T.G., Hogema, B., et al. 2-Methylbutyryl-coenzyme A dehydrogenase deficiency: A new inborn error of L-isoleucine metabolism. Pediatr. Res. 47(6), 830-833 (2000).

    2. Kirkwood-Donelson, K.I., Jarmusch, A.K., Bortner, C.D., et al. Metabolic consequences of erastin-induced ferroptosis in human ovarian cancer cells: An untargeted metabolomics study. Front. Mol. Biosci. 11, 1520876 (2025).

    3. Kalhan, S.C., Guo, L., Edmison, J., et al. Plasma metabolomic profile in nonalcoholic fatty liver disease. Metabolism 60(3), 404-413 (2011).

    4. Van Calcar, S.C., Baker, M.W., Williams, P., et al. Prevalence and mutation analysis of short/branched chain acyl-CoA dehydrogenase deficiency (SBCADD) detected on newborn screening in Wisconsin. Mol. Genet. Metab. 110(1-2), 111-115 (2013).