A diterpene alkaloid with cardioprotective activity
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Fuziline

Item No. 30889

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1α,6α,14α,15α,16β)-20-ethyl-6,16-dimethoxy-4-(methoxymethyl)-aconitane-1,8,14,15-tetrol
CAS Number
80665-72-1
Synonyms
  • Senbusine C
Molecular Formula
C24H39NO7
Formula Weight
453.6
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Chloroform: solubleDMSO: soluble
SMILES
O[C@@H]1C2(C3N4CC)[C@@]([C@@H](OC)C3[C@@](O)([C@@H](O)[C@H](OC)[C@H]([C@]5([H])O)C6)[C@@H]5[C@]26[H])([H])[C@](COC)(C4)CC1
InChi Code
InChI=1S/C24H39NO7/c1-5-25-9-22(10-30-2)7-6-13(26)23-12-8-11-16(27)14(12)24(29,21(28)17(11)31-3)15(20(23)25)18(32-4)19(22)23/h11-21,26-29H,5-10H2,1-4H3/t11-,12+,13-,14+,15?,16-,17+,18-,19+,20?,21-,22-,23?,24+/m0/s1
InChi Key
FPECZWKKKKZPPP-WFAXMRCRSA-N
Origin
Plant/Radix Aconiti Carmichaeli
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $40

    Add

    5 mg

    $132

    Add

    10 mg

    $246

    Add

    25 mg

    $469

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    Fuziline is a diterpene alkaloid that has been found in A. lateralis and has cardioprotective activity.1 It reduces sodium pentobarbital-induced cell death in primary neonatal rat cardiomyocytes when used at concentrations ranging from 0.1 to 10 µM. Fuziline (0.5 µM) reduces the production of reactive oxygen species (ROS) and apoptosis induced by isoproterenol (Item No. 15592) in H9c2 rat cardiomyocytes.2 In vivo, fuziline (3 and 10 mg/kg) reduces isoproterenol-induced myocardial necrosis and fibrosis in rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xiong, L., Peng, C., Xie, X.-F., et al. Alkaloids isolated from the lateral root of Aconitum carmichaelii. Molecules 17(8), 9939-9946 (2012).

    2. Fan, C.-L., Yao, Z.-H., Ye, M.-N., et al. Fuziline alleviates isoproterenol-induced myocardial injury by inhibiting ROS-triggered endoplasmic reticulum stress via PERK/eIF2α/ATF4/Chop pathway. J. Cell Mol. Med. 24(2), 1332-1344 (2020).