Mahanimbine

Mahanimbine is a carbazole alkaloid that has been found in M. koenigii and has diverse biological activities.^1,2,3 It is active against S. aureus and S. pyogenes (MIC₁₀₀ = 50 µg/ml for both).¹ Mahanimbine induces cell cycle arrest at the G₀/G₁ phase and apoptosis in Capan-2 and SW1190 cancer cells when used at a concentration of 7 µM, as well as inhibits proliferation in Capan-2, SW1190, BxPC-3, CFPAC-1, and HPAF-II cancer cells (IC₅₀s = 3.5, 3.5, 16, 64, and 32 µM, respectively).² It decreases body weight gain without affecting food intake and reduces increases in plasma total cholesterol and triglyceride levels in a rat model of high-fat diet-induced obesity when administered orally at a dose of 30 mg/kg.³

WARNING This product is not for human or veterinary use.

1. Ramsewak, R.S., Nair, M.G., Strasburg, G.M., et al. Biologically active carbazole alkaloids from Murraya koenigii. J. Agric. Food Chem. 47(2), 444-447 (1999).

2. Pei, C., He, Q., Liang, S., et al. Mahanimbine exerts anticancer effects on human pancreatic cancer cells by triggering cell cycle arrest, apoptosis, and modulation of AKT/mammalian target of rapamycin (mTOR) and signal transducer and activator of transcription 3 (STAT3) signalling pathways. Med. Sci. Monit. 24, 6975-6983 (2018).

3. Birari, R., Javia, V., and Bhutani, K.K. Antiobesity and lipid lowering effects of Murraya koenigii (L.) spreng leaves extracts and mahanimbine on high fat diet induced obese rats. Fitoterapia 81(8), 1129-1133 (2010).