A tobacco-specific nitrosamine carcinogen
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N-Nitroso-N-methyl-4-Aminobutyric Acid

Item No. 30911

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(methylnitrosoamino)-butanoic acid
CAS Number
61445-55-4
Synonyms
  • NMBA
Molecular Formula
C5H10N2O3
Formula Weight
146.1
Purity
≥95%
Formulation (Request formulation change)
A neat oil
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:7): 0.12 mg/mlDMSO: 20 mg/mlEthanol: 25 mg/ml
λmax
231 nm
SMILES
OC(CCCN(C)N=O)=O
InChi Code
InChI=1S/C5H10N2O3/c1-7(6-10)4-2-3-5(8)9/h2-4H2,1H3,(H,8,9)
InChi Key
SJLBIPLIGYWGJV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $141

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    25 mg

    $317

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    50 mg

    $599

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    100 mg

    $1,127

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    Cayman Chemical
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    ENVIRONMENTAL TOXICOLOGY TOOLS & SERVICES
    Product Description

    N-Nitroso-N-methyl-4-aminobutyric acid (NMBA) is a tobacco-specific nitrosamine carcinogen.1 It is oxidized to the reactive metabolite methyl-2-oxopropylnitrosamine (MOPN) in isolated rat liver mitochondria.2 NMBA induces bladder transitional cell carcinomas in rats when administered in the drinking water at a concentration of 300 mg/L per day.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Djordjevic, M.V., Brunnemann, K.D., and Hoffmann, D. Identification and analysis of a nicotine-derived N-nitrosamino acid and other nitrosamino acids in tobacco. Carcinogenesis 10(9), 1725-1731 (1989).

    2. Janzowski, C., Landsiedel, R., Gölzer, P., et al. Mitochondrial formation of β-oxopropyl metabolites from bladder carcinogenic ω-carboxyalkylnitrosamines. Chem. Biol. Interact. 90(1), 23-33 (1994).

    3. Lijinsky, W., Reuber, M.D., Saavedra, J.E., et al. Carcinogenesis in F344 rats by N-nitrosomethyl-n-propylamine derivatives. J. Natl. Cancer Inst. 70(5), 959-963 (1983).