An RBP4 antagonist
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A-1120

Item No. 30921

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[[4-[2-(trifluoromethyl)phenyl]-1-piperidinyl]carbonyl]amino]-benzoic acid
CAS Number
1152782-19-8
Molecular Formula
C20H19F3N2O3
Formula Weight
392.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mMEthanol: 25 mM
λmax
226, 252 nm
SMILES
FC(F)(F)C1=CC=CC=C1C2CCN(C(NC3=C(C(O)=O)C=CC=C3)=O)CC2
InChi Code
InChI=1S/C20H19F3N2O3/c21-20(22,23)16-7-3-1-5-14(16)13-9-11-25(12-10-13)19(28)24-17-8-4-2-6-15(17)18(26)27/h1-8,13H,9-12H2,(H,24,28)(H,26,27)
InChi Key
MEAQCLPMSVEOQF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $134

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    10 mg

    $240

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    Product Description

    A-1120 is a non-retinoid retinol binding protein 4 (RBP4) antagonist (Ki = 8.3 nM for disruption of RBP4 binding to transthyretin).1 It is selective for RBP4 over cellular retinol binding protein 1 (CRBP1; IC50s = 0.09 and >30 µM, respectively, in radioligand binding assays), as well as a panel of G protein-coupled receptors, kinases, and enzymes. A-1120 (30 mg/kg) reduces serum levels of RBP4 and retinol in mice. It also inhibits retinal bisretinoid accumulation in the Abca4-/- mouse model of enhanced retinal lipofuscinogenesis-induced macular degeneration.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Montani, A., Wang, Z., Conn, M., et al. Identification and characterization of a non-retinoid ligand for retinol-binding protein 4 which lowers serum retinol-binding protein 4 levels in vivo. The Journal of Biological Chemisty 284(12), 7673-7680 (2009).

    2. Dobri, N., Qin, Q., Kong, J., et al. A1120, a nonretinoid RBP4 antagonist, inhibits formation of cytotoxic bisretinoids in the animal model of enhanced retinal lipofuscinogenesis. Invest. Ophthalmol. Vis. Sci. 54(1), 85-95 (2013).