An inhibitor of FBPase
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MB-05032

Item No. 30924

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
P-[5-[2-amino-5-(2-methylpropyl)-4-thiazolyl]-2-furanyl]-phosphonic acid
CAS Number
261365-11-1
Molecular Formula
C11H15N2O4PS
Formula Weight
302.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
NC1=NC(C2=CC=C(P(O)(O)=O)O2)=C(CC(C)C)S1
InChi Code
InChI=1S/C11H15N2O4PS/c1-6(2)5-8-10(13-11(12)19-8)7-3-4-9(17-7)18(14,15)16/h3-4,6H,5H2,1-2H3,(H2,12,13)(H2,14,15,16)
InChi Key
XJMYIJPPDSZOPN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $69

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    5 mg

    $263

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    MB-05032 is an inhibitor of fructose-1,6-bisphosphatase (FBPase; IC50s = 16 and 61 nM for human and rat liver FBPase, respectively).1 It increases glucose utilization and enhances glucose-stimulated insulin release in MIN6 insulinoma cells when used at concentrations of 50, 100, and 200 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dang, Q., Kasibhatla, S.R., Reddy, K.R., et al. Discovery of potent and specific fructose-1,6-bisphosphatase inhibitors and a series of orally-bioavailable phosphoramidase-sensitive prodrugs for the treatment of type 2 diabetes. J. Am. Chem. Soc. 129(50), 15491-15502 (2007).

    2. Zhang, Y., Xie, Z., Zhou, G., et al. Fructose-1,6-bisphosphatase regulates glucose-stimulated insulin secretion of mouse pancreatic β-cells. Endocrinology 151(10), 4688-4695 (2010).