A TLR3 antagonist
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CU-CPT4a

Item No. 30951

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(3-chloro-6-fluorobenzo[b]thien-2-yl)carbonyl]-D-phenylalanine
CAS Number
1279713-77-7
Molecular Formula
C18H13ClFNO3S
Formula Weight
377.8
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mM
SMILES
FC1=CC=C(C(Cl)=C(C(N[C@H](CC2=CC=CC=C2)C(O)=O)=O)S3)C3=C1
InChi Code
InChI=1S/C18H13ClFNO3S/c19-15-12-7-6-11(20)9-14(12)25-16(15)17(22)21-13(18(23)24)8-10-4-2-1-3-5-10/h1-7,9,13H,8H2,(H,21,22)(H,23,24)/t13-/m1/s1
InChi Key
IAASQMCXDRISAV-CYBMUJFWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $75

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    1 mg

    $143

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    5 mg

    $516

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    Cayman Chemical
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    Product Description

    CU-CPT4a is a toll-like receptor 3 (TLR3) antagonist (IC50 = 3.44 µM).1 It is selective for TLR3 over TLR4, TLR2/6, TLR1/2, and TLR7 at 27 µM. CU-CPT4a inhibits dsRNA binding to TLR3 with a Ki value of 2.96 µM in a fluorescence anisotropy assay. It decreases poly(I:C)-induced production of TNF-α and IL-1β in RAW 264.7 cells when used at a concentration of 27 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cheng, K., Wang, X., and Yin, H. Small-molecule inhibitors of the TLR3/dsRNA complex. J. Am. Chem. Soc. 133(11), 3764-3767 (2011).