An antimalarial agent
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Halofantrine (hydrochloride)

Item No. 30962

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,3-dichloro-α-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-9-phenanthrenemethanol, monohydrochloride
CAS Number
36167-63-2
Synonyms
  • (±)-Halofantrine
  • SKF 102886
  • WR 171669
Molecular Formula
C26H30Cl2F3NO • HCl
Formula Weight
536.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleMethanol: soluble
λmax
216, 232, 259 nm
SMILES
FC(F)(F)C1=CC2=C3C(C(Cl)=CC(Cl)=C3)=CC(C(O)CCN(CCCC)CCCC)=C2C=C1.Cl
InChi Code
InChI=1S/C26H30Cl2F3NO.ClH/c1-3-5-10-32(11-6-4-2)12-9-25(33)23-16-22-21(14-18(27)15-24(22)28)20-13-17(26(29,30)31)7-8-19(20)23;/h7-8,13-16,25,33H,3-6,9-12H2,1-2H3;1H
InChi Key
WANGFTDWOFGECH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Halofantrine is an antimalarial agent.1 It is active against chloroquine-sensitive and chloroquine-resistant strains of P. falciparum (IC50s = 1.5-2.5 and 1.3-3.9 µg/L, respectively). Halofantrine reduces parasitemia in a mouse model of P. berghei infection with a 50% curative dose (CD50) value of 15 mg/kg. It also reduces parasitemia in an Aotus monkey model of P. falciparum infection (CD50 = 58.3 mg/kg). Formulations containing halofantrine have been used in the treatment of malaria.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bryson, H., and Goa, K.L. Halofantrine. A review of its antimalarial activity, pharmacokinetic properties and therapeutic potential. Drugs 43(2), 236-258 (1992).