A dual antagonist of 5-HT2C and 5-HT2B receptors
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SB-200646 (hydrochloride)

Item No. 30973

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(1-methyl-1H-indol-5-yl)-N′-3-pyridinyl-urea, monohydrochloride
CAS Number
143797-62-0
Molecular Formula
C15H14N4O • HCl
Formula Weight
302.8
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mM
SMILES
O=C(NC1=CC(C=CN2C)=C2C=C1)NC3=CC=CN=C3.Cl
InChi Code
InChI=1S/C15H14N4O.ClH/c1-19-8-6-11-9-12(4-5-14(11)19)17-15(20)18-13-3-2-7-16-10-13;/h2-10H,1H3,(H2,17,18,20);1H
InChi Key
IGRYPUQJEDJLHC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $128

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    10 mg

    $236

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    Product Description

    SB-200646 is a dual antagonist of the serotonin (5-HT) receptor subtypes 5-HT2C (Ki = 125 nM in isolated rat cortex) and 5-HT2B (pA2 = 7.5 in rat stomach fundus preparations).1 It is selective for 5-HT2C and 5-HT2B over 5-HT1A, 5-HT2A, 5-HT1D, 5-HT3, benzodiazepine, GABAA, α1-, α2A-, α2B-, β1-, and β2-adrenergic, dopamine D1 and D2, and histamine H1 receptors (Kis = >10 µM for all). SB-200646 (20 and 40 mg/kg) reverses mCPP-induced hypophagia and decreases in social interaction time, indicating anxiolytic-like behavior, in rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kennett, G.A., Wood, M.D., Glen, A., et al. In vivo properties of SB 200646A, a 5-HT2C/2B receptor antagonist. Br. J. Pharmacol. 111(3), 797-802 (1994).